Metastasis

Metastasis, or metastatic disease, is the spread of a cancer or other disease from one organ or part to another not directly connected with it. The new occurrences of disease thus generated are referred to as metastases /mə ˈtæs tə siːz/ (sometimes abbreviated "mets"). It was previously thought that only malignant tumor cells and infections have the capacity to metastasize (also spelled metastasise); new research has caused this to be reconsidered. The existence of metastatic cancers in the absence of primary tumors also suggests that metastasis is not always caused by malignant cells that leave primary tumors.Metastasis is a Greek word meaning "displacement", from μετά, meta, "next", and στάσις, stasis, "placement".

Cancer occurs after a single cell in a tissue is progressively genetically damaged to produce cells with uncontrolled proliferation. This uncontrolled proliferation by mitosis produces a primary heterogeneic tumour. The cells which constitute the tumor eventually undergo metaplasia, followed by dysplasia then anaplasia, resulting in a malignant phenotype. This malignancy allows for invasion into the circulation, followed by invasion to a second site for tumorigenesis.

Metastases (film)

Metastases (Croatian: Metastaze) is a 2009 Croatian crime drama film about some of the most common problems in post-war Croatia, including football hooliganism, drug addiction and alcoholism. It was directed by Branko Schmidt.

Plot

The film follows the lives of four unconventional friends from a Zagreb neighbourhood – Krpa, Filip, Kizo and Dejo. All of them are football fans and Dinamo Zagreb supporters.

Krpa is an antisocial football hooligan who constantly abuses his wife. Throughout the film, he also insults and physically attacks several people who complain about his behaviour. In the final scene, he robs a betting shop and is involved in a foot chase with two police officers.

Filip is a drug addict who spent three years in a rehabilitation program in Spain. When he returns to Zagreb at the beginning of the film, his parents try to persuade him to find a job in order to prevent him from returning to his previous habits. The same day, he reunites with the remaining three members of the group at a neighbourhood bar.