TRP
TRP may refer to:
TYRP1
Tyrosinase-related protein 1, also known as TYRP1, is an enzyme which in humans is encoded by the TYRP1 gene.
Function
Tyrp1 is a melanocyte-specific gene product involved in melanin synthesis. While mouse Tyrp1 possesses dihydroxyindole carboxylic acid oxidase activity, the function in human melanocytes is less clear. In addition to its role in melanin synthesis, Tyrp1 is involved in stabilizing of tyrosinase protein and modulating its catalytic activity. Tyrp1 is also involved in maintenance of melanosome structure and affects melanocyte proliferation and melanocyte cell death.
Clinical significance
Mutations in the mouse Tyrp1 gene are associated with brown pelage and in the human TYRP1 gene with oculocutaneous albinism type 3 (OCA3). An allele of TYRP1 common in Solomon Islanders results in blond hair. Although the phenotype is similar to Northern European blond hair, this allele is not found in Europeans.
Regulation
The expression of TYRP1 is regulated by the microphthalmia-associated transcription factor (MITF).
Dopachrome tautomerase
Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2), also known as DCT, is a human gene. Its expression is regulated by the microphthalmia-associated transcription factor (MITF).
See also
References
Further reading
Mess Around
"Mess Around", written by Atlantic Records president and founder Ahmet Ertegün under the pseudonym of A. Nugetre, or "Nuggy" was one of Ray Charles’ first hits. Ertegün claims his inspiration for writing "Mess Around" was Pete Johnson. Earlier versions of the tune, a New Orleans boogie piano riff, can be heard throughout the early 1930s and 1940s the earliest of all being "Cow Cow Blues" from Charles "Cow Cow" Davenport in 1928. Dr John has spoken about the origin of this tune on his "Dr John Teaches New Orleans Piano" series of DVDs.
The lyrics urge listeners to dance ("mess around"), along with a few other key phrases, notably the "girl with the red dress on", harkening back to "Pinetop's Boogie Woogie", the early boogie woogie classic. "Mess Around" became a big R&B charted hit when released as a single in early 1953.
Cover versions and cultural references
Podcasts:
