Mazda MPV
The Mazda MPV (Multi-Purpose Vehicle) is a minivan manufactured by Mazda. Introduced in 1989 as a rear-wheel-drive model with optional selectable four-wheel drive, it was replaced in 2000 with a front-wheel-drive-only version. Over one million MPV models had been produced since its introduction.
First generation (LV; 1989–1999)
The minivan boom of the 1980s caught the Japanese car makers by surprise. Each maker had its own response: Toyota was first with an adaptation of their mid-engined Van, based on the Japanese TownAce in 1984. Nissan and Mitsubishi quickly followed suit with conversions of cargo vans in 1987, but all of them were small and only offered four-cylinder engines, which limited their popularity in North America. Mazda, as a stopgap measure, sold imported Kia Besta mid-engined 4-cylinder vans through Canadian Mazda dealers. Approximately 150 were sold in Canada over the 1987 & 1988 model years. These were essentially a Korean-built version of Mazda's Bongo van.
MPV
MPV or mpv may refer to:
Computing
Transport
Road
- Mini MPV, a small MPV automobile
- Compact MPV, a medium sized MPV automobile
- Luxgen7 MPV
- Mazda MPV
Rail
- British Rail MPV, a version of the Windoff MPV used in the United Kingdom
Military
- Mahindra Mine Protected Vehicle, an Indian armored personnel carrier
- Okapi MPV, a South African mine-protected vehicle
Science and medicine
MPV17
Protein MPV17 is a protein that in humans is encoded by the MPV17 gene. It is a mitochondrial inner membrane protein, which has a so far largely unknown role in mtDNA maintenance. Protein MPV17 is expressed in human pancreas, kidney, muscle, liver, lung, placenta, brain and heart. Human MPV17 is the orthologue of the mouse kidney disease gene, Mpv17. Loss of function has been shown to cause hepatocerebral mtDNA depletion syndromes (MDS) with oxidative phosphorylation failure and mtDNA depletion both in affected individuals and in Mpv17−/− mice.
Function
This protein was first thought to be a peroxisomal protein, but in 2006, Spinazzola demonstrated that it is a mitochondrial inner membrane protein that is implicated in the formation of reactive oxygen species (ROS).
Restoration of Mpv17 expression in a Mpv17-/- mice restore mtDNA copy number, suggesting MPV17 is involved in mtDNA copy number, and in mtDNA maintenance.
MPV17 seems to be also involved in apoptosis in podocytes, and involved in ROS.
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