After a period as Member of the Italian Parliament for the Movimento Sociale Italiano, Gasparri served as an Alleanza Nazionale member. During the course of his career he has served as Minister of Communications (2001 to 2005 in the Berlusconi II Cabinet). It was during his time in this role that he pushed for the law known popularly as the "legge Gasparri". In the XVI legislature he is the president of the senators of The People of Freedom.
In the wake of Barack Obama's election in November 2008, Gasparri declared on RAI that "with Obama in the White House, perhaps al-Qaeda is happier".
Gasparri was heavily criticized for the declaration by the Democratic Party.