Wuerker graduated from Lewis & Clark College with a BA in 1979. While at Lewis & Clark, he served as the chief editorial cartoonist for The Pioneer Log, the weekly student newspaper.
He has published two collections of cartoons, Standing Tall in Deep Doo Doo, A Cartoon Chronicle of the Bush Quayle Years (Thunder's Mouth Press, 1991) and Meanwhile in Other News... A Graphic Look at Politics in the Empire of Money, Sex and Scandal (Common Courage Press, 1998). He illustrated the book The Madness of King George (Common Courage Press, 2003) by Michael K. Smith.