Matthias Grünewald (c. 1470 – August 31, 1528) was a German Renaissance painter of religious works who ignored Renaissance classicism to continue the style of late medieval Central European art into the 16th century. His first name is also given as Mathis and his surname as Gothart or Neithardt. Only ten paintings—several consisting of many panels—and thirty-five drawings survive, all religious, although many others were lost at sea in the Baltic on their way to Sweden as war booty. His reputation was obscured until the late nineteenth century, and many of his paintings were attributed to Albrecht Dürer, who is now seen as his stylistic antithesis. His largest and most famous work is the Isenheim Altarpiece created 1506 to 1515 or perhaps 1512 to 1516.
The details of his life are unusually unclear for a painter of his significance at this date, despite the fact that his commissions show that he had reasonable recognition in his own lifetime. The first source for his biography is the German art historian Joachim von Sandrart, who describes him around 1505 working on the exterior decoration of an altarpiece by Albrecht Dürer in Frankfurt. This is the sort of work typically performed by apprentices and therefore an estimate of his age can be reached, suggesting he was born in 1480-83. Sandrart records that Grünewald had as an apprentice the painter Hans Grimmer, who would become famous in his time, but most of whose works were lost in the Thirty Years' War. Sandrart describes Grünewald as leading a withdrawn and melancholy life, and marrying unhappily.