Marksville may refer to:
Marksville is a small city in and the parish seat of Avoyelles Parish, Louisiana, United States. The population was 5,702 at the 2010 census, an increase of 165 over the 2000 tabulation of 5,537.
Louisiana's first land-based casino, Paragon Casino Resort, opened in Marksville in June 1994. It is operated by the federally recognized Tunica-Biloxi Indian Tribe, which has a reservation in the parish.
Marksville is named after Marc Eliche (Marco Litche, as recorded by the Spanish), a Jewish-Italian immigrant who established a trading post after his wagon broke down in this area. He was a Sephardic Jewish trader from Italy, believed to be from Venice. His Italian name was recorded by a Spanish priest as Marco Litche, and as Marc Eliche by French priests after his trading post was established about 1794. Marksville was noted on Louisiana maps as early as 1809, after the United States acquired the territory in the Louisiana Purchase in 1803. Eliche later donated the land that became the Courthouse Square. It is still the center of Marksville.