Markopoulo Oropou (Greek: Μαρκόπουλο Ωρωπού) is a town and a former community of East Attica, Greece. Since the 2011 local government reform it is part of the municipality Oropos, of which it is a municipal unit.
Markopoulo Oropou is situated 3 km south of the South Euboean Gulf coast. It is 4 km southeast of Nea Palatia and 35 km north of Athens. The community Markopoulo Oropou consists of the town Markopoulo and the villages Neo Livyssi, Agia Varvara and Bafi.