Lair

Lair may refer to:

LAIR1

Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene. LAIR1 has also been designated as CD305 (cluster of differentiation 305).

Function

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

Interactions

LAIR1 has been shown to interact with PTPN11 and PTPN6.

References

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Mark

Mark may refer to:

Christianity

Currency

Mark (dinghy)

The Mark is a single-hander class of small sailing dinghy. The design probably first appeared in the 1960s, at about the same time as the Laser, but never took off as a popular racing class. The Mark is 12 feet (3.7 m) in length, with forward and side buoyancy compartments. A 19 feet (5.8 m) free standing rotating mast stepped far forward in the front buoyancy compartment supports a mainsail.

Gospel of Mark

The Gospel According to Mark (Greek: τὸ κατὰ Μᾶρκον εὐαγγέλιον, to kata Markon euangelion), the second book of the New Testament, is one of the four canonical gospels and the three synoptic gospels. It was traditionally thought to be an epitome (summary) of Matthew, which accounts for its place as the second gospel in the Bible, but most scholars now regard it as the earliest of the gospels. Most modern scholars reject the tradition which ascribes it to Mark the Evangelist, the companion of Peter, and regard it as the work of an unknown author working with various sources including collections of miracle stories, controversy stories, parables, and a passion narrative.

Mark tells of the ministry of Jesus from his baptism by John the Baptist to his death and burial and the discovery of the empty tomb – there is no genealogy or birth narrative, nor, in the original ending at chapter 16, any post-resurrection appearances. It portrays Jesus as a heroic man of action, an exorcist, healer and miracle worker. Jesus is also the Son of God, but he keeps his identity secret, concealing it in parables so that even the disciples fail to understand. All this is in keeping with prophecy, which foretold the fate of the messiah as Suffering Servant. The gospel ends, in its original version, with the discovery of the empty tomb, a promise to meet again in Galilee, and an unheeded instruction to spread the good news of the resurrection.