Mankind

Mankind may refer to:

See also

Mankind (video game)

Mankind is a massively multiplayer online real-time strategy (MMORTS) computer game.

History

Mankind was initially published in December 1998 by the French computer game developer Vibes Online Gaming. After the transfer of Vibes to its Asian partner, the game was bought by O2 Online Entertainment Ltd. and while still active today, is being primarily maintained by Quantex since 2008.

Estimates of the number of active players are hard to come by - while the official site claimed both 145,000 and "more than 200,000" players on the same page, these figures likely included inactive as well as trial accounts. According to an interview with an O2OE spokesman, just about 3,000 accounts were active anymore in May 2003.

During the game rework of Quantex in early 2009, the graphic engine of Mankind got fully ported to DirectX 9 and full support for Windows Vista got implemented. Further, dozens of small improvements got implemented.

In December 2015 the Mankind servers were shut down.

No Code

No Code is the fourth studio album by the American alternative rock band Pearl Jam, released on August 27, 1996 through Epic Records. Following a troubled tour for its previous album, Vitalogy (1994), in which Pearl Jam engaged in a much-publicized boycott of Ticketmaster, the band went into the studio to record its follow-up. The music on the record was more diverse than what the band had done on previous releases, incorporating elements of garage rock, worldbeat, psychedelia, and experimentalism.

Although No Code debuted at number one on the Billboard 200, it left a large section of the band’s fanbase unsatisfied and quickly fell down the charts. Critical reviews were also mixed, with praise to the musical variety but the album being considered inconsistent. The album became the first Pearl Jam album to not reach multi-platinum status, receiving a single platinum certification by the RIAA in the United States.

Recording

For its fourth album, Pearl Jam again worked with producer Brendan O'Brien, with whom they had worked on predecessors Vs. (1993) and Vitalogy (1994). No Code was the band's first album with drummer Jack Irons, who had joined the band as Vitalogy was being completed. Following the summer U.S. leg of the band's Vitalogy Tour, the band began work on No Code in Chicago, Illinois in July 1995 during the infamous Chicago heat wave. The Chicago sessions lasted a week at the Chicago Recording Company. During a break in a string of make-up dates for the 1995 tour the band went into the studio for a week-long session in New Orleans, Louisiana, where the band recorded "Off He Goes". The rest of the recording took place in the first half of 1996 in Seattle, Washington at Studio Litho, which is owned by guitarist Stone Gossard. The album was then mixed by O'Brien at his mixing facility at Southern Tracks in Atlanta, Georgia.

TCP

TCP may refer to:

Science and technology

Computing

Medicine

Chemistry

Organizations

CCL5

Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene. It is also known as RANTES (regulated on activation, normal T cell expressed and secreted).

Function

CCL5 is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, CCL5 also induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. It is also an HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans.

RANTES was first identified in a search for genes expressed "late" (3–5 days) after T cell activation. It was subsequently determined to be a CC chemokine and expressed in more than 100 human diseases. RANTES expression is regulated in T lymphocytes by Kruppel like factor 13 (KLF13). RANTES, along with the related chemokines MIP-1alpha and MIP-1beta, has been identified as a natural HIV-suppressive factor secreted by activated CD8+ T cells and other immune cells. Recently, the RANTES protein has been engineered for in vivo production by Lactobacillus bacteria, and this solution is being developed into a possible HIV entry-inhibiting topical microbicide.

T-complex 1

T-complex protein 1 subunit alpha is a protein that in humans is encoded by the TCP1 gene.

Function

This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

Interactions

T-complex 1 has been shown to interact with PPP4C and HDAC3. CCT also directly interacts with lectin type oxidized LDL receptor-1 (LOX-1) while its ligand oxidized low density lipoprotein (OxLDL) disassociates CCT from LOX-1.

References

Further reading