Manic

Manic may refer to:

Persons

Toponyms

Others

See also

Manic (film)

Manic is a 2001 American drama film directed by Jordan Melamed and written by Michael Bacall and Blayne Weaver. It was shown at several film festivals in 2001 and 2002, including the Sundance Film Festival. The region 1 DVD was released January 20, 2004. This is also the first time Gordon-Levitt and Deschanel have worked together as each other's main interest in a film, the second being (500) Days of Summer.

Plot

After brutally beating another teen with a baseball bat during a baseball game, Lyle Jensen, an impulsive and aggressive teen, is admitted to the juvenile psychiatric ward of a hospital along with other troubled teens: Tracy, Chad, Michael, Kenny, and Sara. Lyle is placed in a room with Kenny, a reticent 13-year-old, and form some semblance of a sibling relationship. Lyle has problems adjusting to the confinements of the institution and it is Dr. David Monroe's job to get them to talk in group therapy sessions.

Lyle finds himself attracted to Tracy. She is reluctant to become close to him due to her low self-esteem and fear of him. Tracy has constant terrible nightmares. Lyle becomes curious about why she screams at night and later finds out she is a victim of rape. In their room, Kenny and Lyle begin a discussion about their fathers, at which point Kenny announces that his stepfather is going to visit him. After an disastrous visit, it is revealed that the stepfather sexually molests him. Due to a confrontation between Dr. Monroe, Kenny, and his stepfather, Kenny is transferred to another unit of the institution.

T.J. Perkins

Teddy James "T.J." Perkins (born September 3, 1984) is an American professional wrestler of Filipino descent. He is best known for his work in Total Nonstop Action Wrestling (TNA), where he is a former TNA X Division Champion. In TNA, he used the ring name Manik, which is based on the Suicide gimmick. He also works on the independent circuit, sometimes under his initials TJP or under a mask as Puma (also stylized as PUMA).

Professional wrestling career

Training and early career (1998–2003)

Perkins first began his training at the age of 13, training at a local lucha libre school in his hometown of Los Angeles, California. Perkins debuted in January 1999 at the age of 14, under a mask as promoters felt he looked too young to be wrestling. Initially, he wrestled under the ring name T.J. Perkins, utilising "Pinoy Boy" as a nickname. In order to attend shows, he had to not attend school most Fridays. He wrestled on independent cards in California, Nevada, Arizona, and Mexico during his first two years.

DMT

DMT may refer to the following:

Chemical substances

Sports

Other uses

2,alpha-DMT

2,alpha-DMT, or 2,α-dimethyltryptamine, is a tryptamine and a lesser-known psychedelic drug. It is the 2,a-dimethyl analog of DMT. 2,α-DMT was first synthesized by Alexander Shulgin. In his book TiHKAL (Tryptamines I Have Known and Loved), Shulgin lists the dosage as 300-500 mg, and the duration as 7-10 hours. 2,α-DMT causes mydriasis and paresthesia. It also produces a calm, drunk-like feeling. Very little data exists about the pharmacological properties, metabolism, and toxicity of 2,α-DMT.

References

External links

DMT1

The divalent metal transporter 1 (DMT1), also known as natural resistance-associated macrophage protein 2 (NRAMP 2), and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 (solute carrier family 11, member 2) gene. DMT1 represents a large family of orthologous metal ion transporter proteins that are highly conserved from bacteria to humans.

As its name suggests, DMT1 binds a variety of divalent metals including cadmium (Cd²⁺), copper (Cu²⁺), and zinc (Zn^2+,,) however it is best known for its role in transporting ferrous iron (Fe²⁺); DMT1 expression is regulated by body iron stores to maintain iron homeostasis. DMT1 is also important in the absorption and transport of manganese (Mn²⁺). In the digestive tract, it is located on the apical membrane of enterocytes, where it carries out H⁺ coupled transport of divalent metal cations from the intestinal lumen into the cell.

Role in neurodegenerative diseases

Toxic accumulation of divalent metals, especially iron and/or manganese, are frequently discussed aetiological factors in a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. DMT1 may be the major transporter of manganese across the blood brain barrier and expression of this protein in the nasal epithelium provides a route for direct absorption of metals into the brain. DMT1 expression in the brain may increase with age, increasing susceptibility to metal induced pathologies. DMT1 expression is found to be increased in the substantia nigra of Parkinson's patients and in the ventral mesencephalon of animal models intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) - a neurotoxin widely used experimentally to produce Parkinsonian symptoms.