Ursolic acid
Ursolic acid (sometimes referred to as urson, prunol, malol, or 3-beta-3-hydroxy-urs-12-ene-28-oic-acid), is a pentacyclic triterpenoid identified in the epicuticular waxes of apples as early as 1920 and widely found in the peels of fruits, as well as in herbs and spices like rosemary and thyme.
Natural occurrence
Ursolic acid is present in many plants, such as Mirabilis jalapa, as well as in many fruits and herbs used in daily life (e.g. apples, basil, bilberries, cranberries, elder flower, peppermint, rosemary, lavender, oregano, thyme, hawthorn, and prunes). Apple peels contain large quantities of ursolic acid and related compounds.
Potential biochemical effects
A number of potential biochemical effects of ursolic acid have been investigated, but there has been no clinical study demonstrating benefits to human health. In vitro, ursolic acid inhibits the proliferation of various cancer cell types by inhibiting the STAT3 activation pathway, and may also decrease proliferation of cancer cells and induce apoptosis. Ursolic acid has also been shown to inhibit JNK expression and IL-2 activation of JURKAT leukemic T Cells leading to the reduction in proliferation and T cell activation. Ursolic acid is a weak aromatase inhibitor (IC50 = 32 μM) and has been shown to increase the amount of muscle and brown fat and decrease white fat obesity and associated conditions when added to diets fed to mice. Under physiological concentrations, ursolic acid also induces eryptosis (the apoptosis-like suicidal cell death in defective red blood cells). It has been found to reduce muscle atrophy and to stimulate muscular growth in mice, also shows a potential cardioprotection.
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Whistle's Party
by: MolellaAha aha aha aha aha
Ohhhh all the boyfriend beware
Ehi baby what's up? What you doin' tonight?
Oh yeah I'm going down to the Whistle's Party
The man, leave your boyfriend home
and why don't you come with me
because It's the place that's gonna make you feel good
I don't wanna in not
but if you wanna come you just call me, ok?
Ciao baby
In the beginning
in this time to movin to the left and dancing to the
right
we shake our bodies at the discotek
but now is the time to just feel good
Welcome to the place that feels good
Welcome to the place that feels good
Welcome to the place that feels good
Welcome to the place that feels good
Walking down the street I'm thinking about you
I'm thinking all the times the times we're together
if you wanna come with me blow your whistle to the beat
here I am all alone waiting for you to phone
Blow your whistle
let me blow your whistle the whistle
let me blow your whistle the whistle the whistle
let me blow your whistle the whistle
let me blow your whistle the whistle
blow your whistle
Welcome to the place that feels good
Welcome to the place that feels good
Welcome to the place that feels good
Welcome to the place that feels good
I'm walking down the street I'm thinking about you
I'm thinking all the times the times we're together
if you wanna come with me blow your whistle to the beat
here I am all alone waiting for you to phone
Blow your whistle
let me blow your whistle the whistle
let me blow your whistle the whistle the whistle
let me blow your whistle the whistle
let me blow your whistle the whistle
blow your whistle
Blow your whistle
let me blow your whistle the whistle
let me blow your whistle the whistle the whistle
let me blow your whistle the whistle
let me blow your whistle the whistle