MADD (gene)

MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene.

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.

References

Further reading

Jakeš

Jakeš is a village in the municipality of Vukosavlje, Republika Srpska, Bosnia and Herzegovina.

References

Jake

Jake may refer to:

See also

Rise of the Cybermen

"Rise of the Cybermen" is the fifth episode of the second series of the British science fiction television programme Doctor Who. The episode introduces a non-extraterrestrial reinvention of the Cybermen, as well as a parallel universe which would serve as a recurring plot element in the series. It is the first part of a two-part story, the concluding part being "The Age of Steel". The TARDIS becomes stranded in an alternative universe where Rose Tyler's father is alive and corporations are closely involved with the British government; one such corporation is Cybus Industries, which is being countered by an underground resistance. The Doctor, Rose and Mickey Smith discover a plot by Cybus co-founder John Lumic to convert the population of London into monotonous cybernetic creatures resembling enemies the Doctor has faced before.

The episode was first broadcast on 13 May 2006. It was directed by Graeme Harper, who became the first and so far only man in the show's history to have directed episodes in both the original and revived runs of the series: he previously directed the acclaimed serial The Caves of Androzani in 1984, and Revelation of the Daleks in 1985.