| "Instinct" | |||
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| Dollhouse episode | |||
| Episode no. | Season 2 Episode 2 |
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| Directed by | Marita Grabiak | ||
| Written by | Michele Fazekas Tara Butters |
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| Production code | 2APK03 | ||
| Original air date | October 2, 2009 | ||
| Episode chronology | |||
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| List of Dollhouse episodes | |||
"Instinct" is the 2nd episode of the second season of the American science fiction television series Dollhouse and the show's 15th episode overall. The episode was written by Michele Fazekas and Tara Butters and directed by Marita Grabiak, the first in the series she has directed. It aired in the United States on Fox on October 2, 2009.
In this episode, Echo has been imprinted as a mother of a child. However Topher has managed to change Echo on a glandular level, giving Echo strong maternal instincts. This unfortunately causes Echo to be paranoid causing her to kidnap the child. Ballard not only has to find Echo, but its forced to face his past as Madeline Costley, known to Ballard as Mellie, comes back into the Dollhouse for a diagnostic.
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Plot [link]
The episode starts with Ballard walking into Topher's office inspecting the chair. Topher walks in and they discuss Echo's current engagement. Topher notes that he has just opened up a new world to imprinting. By making changes to the brain, he can theoretically program it to fight cancer or even be telekinetic.
On engagement, Echo wakes up in the middle of night, to breastfeed "her" child. In the morning, Echo wakes up and proceeds to take Jack (the baby) downstairs for breakfast. Her husband, Nate who has been working in his home office comes out and is about to leave for work. It is clear that Nate is not prepared to be a father as he is reluctant to hold Jack, while Echo makes coffee. As Echo sees Nate off to work, she notices a black van parked across the street.
In the park, Sierra is on the same engagement acting as one of Echo's friends. Echo tells Sierra about Nate's shortcomings as a father and believes he is having an affair or is engaged in illegal activities. Sierra chalks it up to hormones, but Echo express her paranoia at the black van parked across the street. Sierra tells Echo she is sleep deprived and she needs a good nights rest.
Back at home, Echo is unable to let it go, and begins to rummage through Nate's home office. When Nate comes home, Echo asks Nate "who she is?" referring to some photos she found in Nate's office. Nate tells Echo that she was a former lover, but has since died and apologises for keeping it from Echo. Nate tells Echo to go to sleep and he will take Jack tonight. However Echo wakes up in the middle of the night, and overhears Nate telling someone on the phone to "get rid of her" and he will get rid of the baby.
At Perrin's residence, Perrin discusses the lack of evidence he has against Rossum with his wife. The doorbell rings and Perrin's wife goes to answer the door. However no one was there and she brings Perrin a stack of documents left at the doorstep.
DeWitt goes to visit Madeline formerly November/Mellie. DeWitt attempts to engage Madeline in idle conversation, but Madeline is suspicious of DeWitt's intentions. DeWitt asks Madeline to come in for a diagnostic, citing she will not take "no" for an answer.
On engagement, Echo attempts to flee the house with Jack. Nate tries to prevent Echo from leaving telling her that her car is in the shop with the baby seat. Nate takes the baby telling Echo to go get some rest, but Echo takes Jack back, citing she needs to feed him. Echo calls Sierra to pick her up. However as she arrives, so does a black van and Echo watches as Sierra is taken away. Dollhouse staff surround the house as Ballard tries to go inside to talk Echo down. However Echo has managed to escape, taking Sierra's car.
In the Dollhouse, Nate is furious with DeWitt. But DeWitt is unmoved citing that with the money Nate has, he could have hired a nanny, but he wanted a mother, someone to bond with his child.
Echo attempts to go to the bank to withdraw money. However she spots the black van and runs. Echo is able to find some police officers who take her back to the station to get her statement. Ballard and Nate arrives, and Echo attempts to flee. Echo is hysterical as Jack is taken away from her.
In the Dollhouse, Madeline is receiving her diagnostic. As they finish, Ballard brings Echo in and attempts to place her in the chair. Echo manages to escape but is cornered and sedated. Ballard notices Madeline is cut, and takes her to see the doctor. Madeline tells Ballard that Echo will be fine, as she knows how it feels to have a child taken away. She reveals that she had a baby daughter, who had terminal cancer. Ballard asks if Madeline is happy now, in which she replies she isn't sad. Echo wakes up and is wiped. However the wipe seems to fail, as Echo punches Topher, knocking him unconscious.
Perrin goes through the documents that were given to him. He realises, the illegal activities that Rossum is engaged in. Perrin's wife says they must follow through with this.
Echo manages to escape the Dollhouse. In DeWitt's office, Topher tries to explain what has happened. Ballard believes that Echo is going to get the baby. DeWitt wonders how it is possible as Echo was wiped. Ballard believes it is because Topher, changed her a glandular level and a normal wipe is not strong enough. Topher agrees and notes that triggering lactation was a step too far. DeWitt orders Ballard to retrieve Echo.
At the house, Nate goes to make a bottle of milk for Jack. DeWitt calls Nate telling him to leave the house now, however the power is shortly cut due to a storm. Nate goes back to the bedroom, but Jack has been already taken. As Nate runs back downstairs, he sees Echo holding the baby and a knife. Nate tries to talk Echo down, but Echo is infuriated when Nate tells Echo, she is not his mother. Echo attempts to slash Nate, but feels as if this is not who she is. Nate apologises for making Echo love Jack and then taking him away. Nate tries to talk Echo down again as Ballard arrives. Nate is successful, as Echo hands Jack back to Nate and walks away.
Ballard follows Echo to a park. Echo tells Ballard that she does not remember her engagements, but she does remember the feelings associated with each engagement such as love, pain and fear. She notes that it is not pretend for her. Ballard offers to tell Topher what is happening and fix it so she doesn't feel like she does now. Echo says it would be worse that way. She is awake now and doesn't want to go back to sleep. The episode ends with Ballard sitting next to Echo on the park bench.
Reception [link]
Reviews [link]
Rachel Reitsleff from iF Magazine said the episode had a huge flaw citing that "one can see where the work required by the viewer to put together what we’re being told about Echo’s evolution could be downright daunting to anyone tuning in for the first time." She also notes that it is extremely hard to relate to the series saying "the arc and standalone elements don’t complement each other very well in “Instinct” – we are told that Echo’s recent experiences are having an effect on her, but we don’t yet see that effect."[1] Eric Goldman of IGN gave the episode a 7. He said, "after that jarring beginning, this turned out to be a somewhat lackluster installment, which unfortunately once again brought up some of the show's problems." He notes that there is no real investment into the characters citing that "even learning that Echo is now remembering everything after an engagement doesn't change the fact that when she's in the midst of an engagement, she is apparently still not herself."[2]
References [link]
- ^ "TV Review: DOLLHOUSE - SEASON TWO - 'Instinct'". iF Magazine. 4 October 2009. https://www.ifmagazine.com/review.asp?article=3528. Retrieved 24 January 2010.[dead link]
- ^ "Dollhouse: "Instinct" Review". "IGN. 3 October 2009. https://tv.ign.com/articles/103/1031230p1.html. Retrieved 24 January 2010.
External links [link]
- "Instinct" at the Internet Movie Database
- "Instinct" at TV.com
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https://wn.com/Instinct_(Dollhouse)
Instinct (film)
Instinct is a 1999 American psychological thriller film starring Anthony Hopkins, Cuba Gooding, Jr., George Dzundza, Donald Sutherland, and Maura Tierney. It was very loosely inspired by Ishmael, a novel by Daniel Quinn. In the United States, the film had the working title Ishmael. In 2000, the film was nominated for and won a Genesis Award in the category of feature film. This was the first film produced by Spyglass Entertainment after Caravan Pictures shut down.
Plot
The film examines the mind of anthropologist Ethan Powell (Hopkins) who has been missing for a few years, living in the jungle with gorillas. He had been convicted of killing and injuring several supposed Wilderness Park Rangers in Africa, and is sent to prison. A bright young psychiatrist (Gooding) tries to find out why he killed them, but becomes entangled in a quest to learn the true history and nature of humankind. Eventually it is revealed that during the course of his stay with the gorillas, the animals accepted Powell as part of their group and that he was attempting to protect his gorilla family when the rangers arrived and started shooting them. He gets a hearing to reveal the truth, but an attack by a vicious guard causes Powell to stop talking again. At the end of the film, Powell escapes from prison, using a pen to dig out the lock on a window and heads back to Africa.
Instinct (TV series)
Instinct (Chinese: 笑看風雲) is a Hong Kong television drama series broadcast by TVB in 1994. Starring Adam Cheng, Ekin Cheng, Roger Kwok, Amy Kwok and Nadia Chan, the series premiered in November 1994 on TVB Jade.
Plot
Wong Tin (Adam Cheng) is a wealthy businessman in Hong Kong. Although he is honest and righteous, he is framed by a business rival. Pau Man-lung (Ekin Cheng) is a ICAC agent tasked with investigating the case. Mutual respect soon develops among Wong Tin and Man-lung. After Man-lung loses his job, he start to work under Wong Tin with his best friend Poon Long-ching (Roger Kwok).
Although Wong Tin is a successful businessman, his personal life is not in good shape. He is divorced and his eldest daughter Wong Lui (Amy Kwok) resents him. Wong Lui develop feelings for Man-lung after her mother died in a car crash. However, Man-lung had already fallen in love with Lam Ching-lit (Nadia Chan).
Cast
Mad (Ne-Yo song)
"Mad" is a song by American pop/R&B singer Ne-Yo. It is the third single from his album Year of the Gentleman and was produced by Stargate and himself.
Music video
The video for the song was directed by Diane Martel. It premiered on AOL on November 25, 2008. The video, shot in black and white, presents a narrative wherein Ne-Yo argues with his girlfriend (played by Faune Chambers). After leaving, in an attempt to save a child from a car accident, someone is fatally hit. At the end of the video, it is revealed that the whole time it has been the ghost of Ne-Yo's character singing, and that it was he who was killed. The video to this song is Part 2 to his song Part of the List.
The music video appears to mirror the 1999 American thriller The Sixth Sense from M. Night Shyamalan, in which Bruce Willis plays a psychologist who is shot by an estranged patient of his. Based on how the film was shot and portrayed, Bruce Willis is shown in many situations as if he is there physically, when in actuality he was murdered by his patient, just as how Ne-Yo appears with his girlfriend, seeming to be there physically and that she is ignoring him due to their earlier argument, when he is actually dead.
IκBα
IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning.
Disease linkage
The gene encoding the IκBα protein is mutated in some Hodgkin's lymphoma cells; such mutations inactivate the IκBα protein, thus causing NF-κB to be chronically active in the lymphoma tumor cells and this activity contributes to the malignant state of these tumor cells.
Interactions
IκBα has been shown to interact with:
References
Further reading
Mad1
Mad1 is a non-essential protein in yeast which has a function in the spindle assembly checkpoint (SAC). This checkpoint monitors chromosome attachment to spindle microtubules and prevents cells from starting anaphase until the spindle is built up. The name Mad refers to the observation that mutant cells are mitotic arrest deficient (MAD) during microtubule depolymerization. Mad1 recruits the anaphase inhibitor Mad2 to unattached kinetochores and is essential for Mad2-Cdc20 complex formation in vivo but not in vitro. In vivo, Mad1 acts as a competitive inhibitor of the Mad2-Cdc20 complex. Mad1 is phosphorylated by Mps1 which then leads together with other activities to the formation of the mitotic checkpoint complex (MCC). Thereby it inhibits the activity of the anaphase-promoting complex/cyclosome (APC/C). Homolog’s of Mad1 are conserved in eukaryotes from yeast to mammals.
Introduction
In the early 90s, yeast genes were identified which mutations resulted in a defect in mitotic arrest in response to microtubule disassembly (mitotic arrest deficient genes - MAD genes). This cells showed during division no mitotic arrest in the presence of microtubule polymerization inhibitors and were therefore not able to delay cell division. The genes identified included the MAD1, MAD2 and MAD3 genes. They are conserved in all eukaryotes and are involved in a pathway that is active in prometaphase to prevent the premature separation of sister chromatids and constitute the so-called spindle assembly checkpoint(SAC). This checkpoint monitors the status of chromosome attachment to the mitotic spindle and inhibits the metaphase to anaphase transition by preventing the activation of the anaphase-promoting complex/cyclosome (APC/C), and thereby the degradation of cell cycle regulators. Mad1 is in this pathway accumulated at unattached kinetochores and acts as a sensor for unattached kinetochores in this machinery.
Basic
Basic may refer to:
