Mad2

Mad2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein. The spindle checkpoint system is a regulatory system that restrains progression through the metaphase-to-anaphase transition. The Mad2 gene was first identified in the yeast S. cerevisiae in a screen for genes which when mutated would confer sensitivity to microtubule poisons. The human orthologues of Mad2 (MAD2L1 and MAD2L2) were first cloned in a search for human cDNAs that would rescue the microtubule poison-sensitivity of a yeast strain in which a kinetochore binding protein was missing. The protein was shown to be present at unattached kinetochores and antibody inhibition studies demonstrated it was essential to execute a block in the metaphase-to-anaphase transition in response to the microtubule poison nocodazole. Subsequent cloning of the Xenopus laevis orthologue, facilitated by the sharing of the human sequence, allowed for the characterization of the mitotic checkpoint in egg extracts.

Metaphase-to-anaphase transition

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Mewithoutyou

by: Mewithoutyou

Don't waste your lips on words I've heard before
Kiss my tired head.
And each letter written wastes your hand, young man
Come and lead me to your bed
You gave me hope that I'd not lost her
And then thought it rather strange to see me smile-
as I don't do too much smiling these days.
She put on happiness like a loose dress
Over pain I'll never know
"So the peace you had," she said,
"I must confess, I'm glad to see it go."
We're two white roses lying frozen just outside his door
I've made you so happy and so sad,
But which should I be more sorry for?
Come kiss my face goodbye,
that space below my eye and above my cheek
Cause I'm faint and fading fast, I see a darkness
And I shall be released.
I'll pass like a fever from this body,
And softly slip into his hands
I tried to love you and I failed,
But I have another plan.
How long, My Lord, how long to sing this song?
And my Lord, how muchmore of this pretending to be strong?
When she stands before your throne
Dressed in beauty not her own
All soft and small, you'll hear her call




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