Myo6

Myosin VI

PDB rendering based on 2bkh.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2bkh, 2bki

Identifiers

Symbols

MYO6; DFNA22; DFNB37

External IDs

OMIM: 600970 MGI: 104785 HomoloGene: 56417 GeneCards: MYO6 Gene

Gene Ontology
Molecular function	• nucleotide binding • motor activity • actin binding • protein binding • calmodulin binding • calmodulin binding • ATP binding • ADP binding • actin filament binding • actin filament binding • minus-end directed microfilament motor activity
Cellular component	• ruffle • nucleus • nucleoplasm • cytoplasm • cytoplasm • Golgi apparatus • cytosol • plasma membrane • coated pit • cell cortex • cytoplasmic membrane-bounded vesicle • unconventional myosin complex • DNA-directed RNA polymerase II, holoenzyme • endocytic vesicle • clathrin coated vesicle membrane • filamentous actin • filamentous actin • nuclear membrane • ruffle membrane • clathrin-coated endocytic vesicle • perinuclear region of cytoplasm • perinuclear region of cytoplasm
Biological process	• intracellular protein transport • endocytosis • endocytosis • synaptic transmission • sensory perception of sound • actin filament-based movement • actin filament-based movement • DNA damage response, signal transduction by p53 class mediator • positive regulation of transcription from RNA polymerase II promoter • regulation of secretion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
76.46 – 76.63 Mb

Chr 9:
80.01 – 80.16 Mb

PubMed search

[1]

[2]

Myosin VI, also known as MYO6, is a protein. It has been found in humans, mice, fruit flies (Drosophila melanogaster), and nematodes (Caenorhabditis elegans).

Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins.[supplied by OMIM]^[1]

Interactions [link]

MYO6 has been shown to interact with GIPC1^[2]^[3] and DAB2.^[4]^[5]

References [link]

^ "Entrez Gene: MYO6 myosin VI". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4646.
^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
^ Aschenbrenner, Laura; Lee TinThu, Hasson Tama (July 2003). "Myo6 Facilitates the Translocation of Endocytic Vesicles from Cell Peripheries". Mol. Biol. Cell (United States) 14 (7): 2728–43. DOI:10.1091/mbc.E02-11-0767. ISSN 1059-1524. PMC 165672. PMID 12857860. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=165672.
^ Morris, Shelli M; Arden Susan D, Roberts Rhys C, Kendrick-Jones John, Cooper Jonathan A, Luzio J Paul, Buss Folma (May 2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic (Denmark) 3 (5): 331–41. DOI:10.1034/j.1600-0854.2002.30503.x. ISSN 1398-9219. PMID 11967127.
^ Inoue, Akira; Sato Osamu, Homma Kazuaki, Ikebe Mitsuo (March 2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochem. Biophys. Res. Commun. (United States) 292 (2): 300–7. DOI:10.1006/bbrc.2002.6636. ISSN 0006-291X. PMID 11906161.

Further reading [link]

Buss F, Luzio JP, Kendrick-Jones J (2001). "Myosin VI, a new force in clathrin mediated endocytosis". FEBS Lett. 508 (3): 295–9. DOI:10.1016/S0014-5793(01)03065-4. PMID 11728438.
Hasson T (2004). "Myosin VI: two distinct roles in endocytosis". J. Cell. Sci. 116 (Pt 17): 3453–61. DOI:10.1242/jcs.00669. PMID 12893809.
Avraham KB, Hasson T, Steel KP et al. (1996). "The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells". Nat. Genet. 11 (4): 369–75. DOI:10.1038/ng1295-369. PMID 7493015.
Bement WM, Hasson T, Wirth JA et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. DOI:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=44240.
Nagase T, Ishikawa K, Nakajima D et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. DOI:10.1093/dnares/4.2.141. PMID 9205841.
Avraham KB, Hasson T, Sobe T et al. (1997). "Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice". Hum. Mol. Genet. 6 (8): 1225–31. DOI:10.1093/hmg/6.8.1225. PMID 9259267.
Buss F, Kendrick-Jones J, Lionne C et al. (1999). "The Localization of Myosin VI at the Golgi Complex and Leading Edge of Fibroblasts and Its Phosphorylation and Recruitment into Membrane Ruffles of A431 Cells after Growth Factor Stimulation". J. Cell Biol. 143 (6): 1535–45. DOI:10.1083/jcb.143.6.1535. PMC 2132970. PMID 9852149. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132970.
Wells AL, Lin AW, Chen LQ et al. (1999). "Myosin VI is an actin-based motor that moves backwards". Nature 401 (6752): 505–8. DOI:10.1038/46835. PMID 10519557.
Buss F, Arden SD, Lindsay M et al. (2001). "Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis". EMBO J. 20 (14): 3676–84. DOI:10.1093/emboj/20.14.3676. PMC 125554. PMID 11447109. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125554.
Melchionda S, Ahituv N, Bisceglia L et al. (2001). "MYO6, the Human Homologue of the Gene Responsible for Deafness in Snell's Waltzer Mice, Is Mutated in Autosomal Dominant Nonsyndromic Hearing Loss". Am. J. Hum. Genet. 69 (3): 635–40. DOI:10.1086/323156. PMC 1235492. PMID 11468689. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1235492.
Yoshimura M, Homma K, Saito J et al. (2001). "Dual regulation of mammalian myosin VI motor function". J. Biol. Chem. 276 (43): 39600–7. DOI:10.1074/jbc.M105080200. PMID 11517222.
Rock RS, Rice SE, Wells AL et al. (2002). "Myosin VI is a processive motor with a large step size". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13655–9. DOI:10.1073/pnas.191512398. PMC 61096. PMID 11707568. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=61096.
Inoue A, Sato O, Homma K, Ikebe M (2002). "DOC-2/DAB2 is the binding partner of myosin VI". Biochem. Biophys. Res. Commun. 292 (2): 300–7. DOI:10.1006/bbrc.2002.6636. PMID 11906161.
Morris SM, Arden SD, Roberts RC et al. (2002). "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton". Traffic 3 (5): 331–41. DOI:10.1034/j.1600-0854.2002.30503.x. PMID 11967127.
Wu H, Nash JE, Zamorano P, Garner CC (2002). "Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking". J. Biol. Chem. 277 (34): 30928–34. DOI:10.1074/jbc.M203735200. PMID 12050163.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ahmed ZM, Morell RJ, Riazuddin S et al. (2003). "Mutations of MYO6 Are Associated with Recessive Deafness, DFNB37". Am. J. Hum. Genet. 72 (5): 1315–22. DOI:10.1086/375122. PMC 1180285. PMID 12687499. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1180285.
Aschenbrenner L, Lee T, Hasson T (2004). "Myo6 Facilitates the Translocation of Endocytic Vesicles from Cell Peripheries". Mol. Biol. Cell 14 (7): 2728–43. DOI:10.1091/mbc.E02-11-0767. PMC 165672. PMID 12857860. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=165672.

PDB gallery

2bkh: MYOSIN VI NUCLEOTIDE-FREE (MDINSERT2) CRYSTAL STRUCTURE

2bki: MYOSIN VI NUCLEOTIDE-FREE (MDINSERT2-IQ) CRYSTAL STRUCTURE

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