Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene.
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
Myosin light chain kinase 4 also known as MYLK4 is an enzyme which in humans is encoded by the MYLK2 gene. MYLK4 is a member of the myosin light-chain kinase family of serine/threonine-specific protein kinases that phosphorylate the regulatory light chain of myosin II.
This protein acts as an enzyme that catalyzes the following reaction: ATP + a protein -> ADP + a phosphoprotein.
MYLK4 is also involved in protein amino acid phosphorylation meaning that it adds a phosphate group onto the molecule.
Not very much is known about the specific functional characteristics of MLYK4, but it has recently been found that the gene may possibly have a role in having at least one driver mutation for cancer. MYLK4 may also be involved in transferase activity, ATP binding, protein serine/threonine kinase activity, and also nucleotide binding. Other names for MYLK4 are CaMLCK like; EG238564; MYLK4; Mylk4; Myosin light chain kinase family, member 4; SgK085; SGK085; Sgk085; Sugen kinase 85; Uncharacterized serine/threonine-protein kinase SgK085. The “Sgk” in the Sgk085 name for MYLK4 stands for to serum- and glucocorticoid-inducible kinases. These are serine/threonine protein kinases (SGKs) whose transcription is kept in check by cell volume, corticoids, and serum.
Myosin light chain kinase 2 also known as MYLK2 is an enzyme which in humans is encoded by the MYLK2 gene.
This gene encodes a myosin light chain kinase, a calcium / calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. The MYLK2 gene expresses skMLCK more prevalently in fast twitch muscle fibers as compared to slow twitch muscle fibers. Calmodulin is composed of two terminal domains (N,C) each containing two E-F hand motifs that bind to Ca2+. Upon saturation of Ca2+, Calmodulin undergoes a conformation change allowing it to bind with a target protein such as skMLCK. An image depicting a similar complex (sdCen/skMLCK2) is shown under myosin light chain kinase. This binding to skMLCK increases the affinity of Ca2+ and ultimately leads to a sustained muscle action.
Mutations in the MYLK2 gene have been linked to midventricular hypertrophic cardiomyopathy.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Artist : Moloko
Album : Statues
Title : Familiar Feeling
Nothing can come close
Nothing can come close
Nothing can come close
I never doubted it
What's for you will not pass you by
I never questioned it
It was decided before I asked why
It's all there ever was
And it's all there ever will be
How could you have questioned us?
It's yourself you deceive
Nothing can come close
To this familiar feeling
We say it all without
Ever speaking
Nothing can come close
To this familiar feeling
We say it all without
Ever speaking
Nothing can come close
To this familiar feeling
We say it all without
Ever speaking
Nothing can come close
To this familiar feeling
We say it all without
Hush now
No need to say the words
At first sight you perfectly heard
Love in all its entirety
Is no less than we deserve
I saw, your face
Some place
I felt this feeling before
Is it deja vu?
Do I somehow know you?
Nothing can come close
To this familiar feeling
We say it all without
Ever speaking
Nothing can come close
To this familiar feeling
We say it all without
Ever speaking
Nothing can come close
To this familiar feeling
We say it all without
Ever speaking
Nothing can come close
To this familiar feeling
We say it all without
Nothing can come close
To this familiar feeling
We say it all without
Ever speaking
Nothing can come close
To this familiar feeling
We say it all without
Ever speaking
Nothing can come close
Nothing can come close
(Ever speaking)
Nothing can come close
To this familiar feeling
Nothing can come close