| V-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MYCL1; LMYC; MYCL; bHLHe38 | ||||||||||||
| External IDs | OMIM: 164850 MGI: 96799 HomoloGene: 3921 GeneCards: MYCL1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4610 | 16918 | |||||||||||
| Ensembl | ENSG00000116990 | ENSMUSG00000028654 | |||||||||||
| UniProt | P12524 | P10166 | |||||||||||
| RefSeq (mRNA) | NM_001033081.2 | NM_008506.2 | |||||||||||
| RefSeq (protein) | NP_001028253.1 | NP_032532.1 | |||||||||||
| Location (UCSC) | Chr 1: 40.36 – 40.37 Mb |
Chr 4: 122.67 – 122.68 Mb |
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| PubMed search | [1] | [2] | |||||||||||
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.[1][2]
MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.[3]
Contents |
Interactions [link]
MYCL1 has been shown to interact with MAX.[4][5]
References [link]
- ^ Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet 72 (2–3): 189–190. DOI:10.1159/000134185. PMID 8978772.
- ^ "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4610.
- ^ Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. PMC 401025. PMID 2548855. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=401025.
- ^ Blackwood, E M; Eisenman R N (Mar. 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science (UNITED STATES) 251 (4998): 1211–1217. DOI:10.1126/science.2006410. ISSN 0036-8075. PMID 2006410.
- ^ FitzGerald, M J; Arsura M, Bellas R E, Yang W, Wu M, Chin L, Mann K K, DePinho R A, Sonenshein G E (Apr. 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene (ENGLAND) 18 (15): 2489–2498. DOI:10.1038/sj.onc.1202611. ISSN 0950-9232. PMID 10229200.
Further reading [link]
- Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene 277 (1–2): 1–14. DOI:10.1016/S0378-1119(01)00697-7. PMID 11602341.
- Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. PMC 401025. PMID 2548855. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=401025.
- Kaye F, Battey J, Nau M et al. (1988). "Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing". Mol. Cell. Biol. 8 (1): 186–95. PMC 363100. PMID 2827002. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=363100.
- De Greve J, Battey J, Fedorko J et al. (1988). "The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs". Mol. Cell. Biol. 8 (10): 4381–8. PMC 365511. PMID 3054516. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=365511.
- DePinho RA, Hatton KS, Tesfaye A et al. (1988). "The human myc gene family: structure and activity of L-myc and an L-myc pseudogene". Genes Dev. 1 (10): 1311–1326. DOI:10.1101/gad.1.10.1311. PMID 3322939.
- Atchley WR, Fitch WM (1995). "Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10217–10221. DOI:10.1073/pnas.92.22.10217. PMC 40767. PMID 7479755. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=40767.
- FitzGerald MJ, Arsura M, Bellas RE et al. (1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene 18 (15): 2489–2498. DOI:10.1038/sj.onc.1202611. PMID 10229200.
- Kumimoto H, Hamajima N, Nishimoto Y et al. (2002). "L-myc genotype is associated with different susceptibility to lung cancer in smokers". Jpn. J. Cancer Res. 93 (1): 1–5. PMID 11802801.
- Suzuki H, Yamashiro K (2002). "L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma". Oncol. Rep. 9 (2): 345–7. PMID 11836605.
- Primdahl H, von der Maase H, Christensen M et al. (2002). "Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ". Oncol. Rep. 9 (3): 551–5. PMID 11956626.
- Demopoulos K, Arvanitis DA, Vassilakis DA et al. (2003). "MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis". J. Cell. Mol. Med. 6 (2): 215–222. DOI:10.1111/j.1582-4934.2002.tb00188.x. PMID 12169206.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Wu R, Lin L, Beer DG et al. (2003). "Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas". Am. J. Pathol. 162 (5): 1603–10. DOI:10.1016/S0002-9440(10)64294-0. PMC 1851191. PMID 12707044. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1851191.
- Kambara T, Sharp GB, Nagasaka T et al. (2004). "Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer". Clin. Cancer Res. 10 (5): 1758–1763. DOI:10.1158/1078-0432.CCR-0779-3. PMID 15014029.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. DOI:10.1038/nature04209. PMID 16189514.
- Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–321. DOI:10.1038/nature04727. PMID 16710414.
- Spinola M, Falvella FS, Galvan A et al. (2007). "Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival". Lung Cancer 55 (3): 271–277. DOI:10.1016/j.lungcan.2006.10.023. PMID 17145094.
External links [link]
- MYCL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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