Sievert

The sievert (symbol: Sv) is a derived unit of ionizing radiation dose in the International System of Units (SI). It is a measure of the health effect of low levels of ionizing radiation on the human body.

Quantities that are measured in sieverts are intended to represent the stochastic health risk, which for radiation dose assessment is defined as the probability of cancer induction and genetic damage.

The sievert is used for radiation dose quantities such as equivalent dose, effective dose, and committed dose. It is used both to represent the risk of the effect of external radiation from sources outside the body, and the effect of internal irradiation due to inhaled or ingested radioactive substances.

Conventionally the sievert is not used for high dose rates of radiation which produce deterministic effects, which is the severity of acute tissue damage which is certain to happen. These effects are compared to the physical quantity absorbed dose measured by the unit gray (Gy).

To enable consideration of stochastic health risk, calculations are performed to convert the physical quantity absorbed dose into equivalent and effective doses, the details of which depend on the radiation type and biological context. For applications in radiation protection and dosimetry assessment the International Commission on Radiological Protection (ICRP) and International Commission on Radiation Units and Measurements (ICRU) have published recommendations and data which are used to calculate these.

MSV

mSv or MSV may refer to:

See also

XIST (gene)

Xist (X-inactive specific transcript) is an RNA gene on the X chromosome of the placental mammals that acts as a major effector of the X inactivation process. It is a component of the Xic - X-chromosome inactivation centre - along with two other RNA genes (Jpx and Ftx) and two protein genes (Tsx and Cnbp2). The Xist RNA, a large (17 kb in humans) transcript, is expressed on the inactive chromosome and not on the active one. It is processed in a similar way to mRNAs, through splicing and polyadenylation. However, it remains untranslated. It has been suggested that this RNA gene evolved at least partly from a protein coding gene that became a pseudogene. The inactive X chromosome is coated with this transcript, which is essential for the inactivation. X chromosomes lacking Xist will not be inactivated, while duplication of the Xist gene on another chromosome causes inactivation of that chromosome.

Function

X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females (see dosage compensation). The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIST gene is expressed exclusively from the XIC of the inactive X chromosome. The transcript is spliced but apparently does not encode a protein. The transcript remains in the nucleus where it coats the inactive X chromosome. Alternatively spliced transcript variants have been identified, but their full length sequences have not been determined.