MOPP (chemotherapy)

MOPP is a combination chemotherapy regimen used to treat Hodgkin's disease. The acronym is derived from the component drugs of the regimen:

(M)ustargen (also known as mechlorethamine, chlormethine, mustine, nitrogen mustard, or MSD)

(O)ncovin (also known as Vincristine or VCR)

(P)rocarbazine (also known as Matulane or Natulan)

(P)rednisone (also known as Deltasone or Orasone)

The treatment is usually administered in four week cycles, often for six cycles. MSD and VCR are administered intravenously, while procarbazine and prednisone are pills taken orally. A newer Hodgkin's lymphoma treatment is ABVD.

C-MOPP involves switching the nitrogen mustard from mechlorethamine to cyclophosphamide. C-MOPP is thus very similar to COPP, using the same 4 agents and differing at most in dosages and timing.

Dosage

History

MOPP was the first combination chemotherapy brought in that achieved a high success rate. It was developed at the National Cancer Institute in the 1960s by a team that included Vincent DeVita, Jr..

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MOPP

MOPP (Mission Oriented Protective Posture) (acronym pronounced as "mop") is a protective gear used by military personnel in a toxic environment, e.g., during a chemical, biological, radiological, or nuclear (CBRN) strike:

Mask carrier — Protects the mask from damage. It is usually worn as part of battle gear for easy access and usually contains a technical manual, extra filter, spare parts, chemical detection papers, and nerve agent antidote kits (NAAK).

Protective mask — Commonly referred to as a gas mask or pro mask. It is designed to filter harmful chemical and biological agents, as well as irradiated particles from the air to allow the wearer to breathe safely. No protective masks filter out gases such as carbon monoxide, and in situations requiring that level of protection, external breathing apparatus is employed.

Over garments — Joint Service Lightweight Integrated Suit Technology (JSLIST) Specially designed clothing to be worn over the normal uniform. These garments are designed to allow maximum airflow for cooling while keeping chemical and biological agents from reaching the skin of the wearer. Some are equipped with a charcoal lining to neutralize some agents. Military personnel often equip over garments with strips of M9 Detector Paper to identify chemical agents on the battlefield they might come in contact with.

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/MOPP

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MOPP (chemotherapy)

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