Motor Neurone Disease Association

The Motor Neurone Disease Association (MND Association) is a British charity, operating in England, Wales and Northern Ireland, established in 1979 by a group of volunteers to coordinate care, support, and research for people affected by amyotrophic lateral sclerosis, which is a form of motor neuron disease (MND) (and also as Charcot disease or, in the United States, Lou Gehrig's disease).

The Association's Chief Executive is Sally Light. Its President is neuroscientist Colin Blakemore. The Patrons of the Association are HRH The Princess Royal, neurologist and four-minute mile record breaker Roger Bannister, entrepreneur and philanthropist Joel Cadbury, palliative medicine consultant Baroness Finlay, neuroscientist, broadcaster and author Baroness Greenfield, world-renowned cosmologist Stephen Hawking (who is living with MND), former Chief Inspector of Schools Sir Chris Woodhead, challenger and entrepreneur Richard Noble OBE, Jamie Niven (Senior Vice President at Sotheby's art dealers in New York and younger son of actor David Niven, who died from MND), former English cricketer and current official Chris Broad, and American businessman James Sherwood.

MNDA

Myeloid cell nuclear differentiation antigen is a protein that in humans is encoded by the MNDA gene.

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' UTR, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.

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