MKL1
MKL/megakaryoblastic leukemia 1 is a protein that in humans is encoded by the MKL1 gene.
Function
The protein encoded by this gene interacts with the transcription factor serum response factor, a key regulator of smooth muscle cell differentiation. It is closely related to MKL2 and myocardin. The encoded protein can shuttle between the cytoplasm and the nucleus, and may help this way transduce signals from the cytoskeleton to the nucleus.
Clinical significance
This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.
References
Further reading
Podcasts:
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by Lolly
Mickey
by: LollyOh, Mickey, you're so fine
You're so fine, you blow my mind
Hey, Mickey, hey, Mickey
Oh, Mickey, you're so fine
You're so fine, you blow my mind
Hey, Mickey, hey, Mickey
Oh, Mickey, you're so fine
You're so fine, you blow my mind
Hey, Mickey, hey, Mickey
Oh, Mickey, you're so fine
You're so fine, you blow my mind
Hey, Mickey
Hey, Mickey
You've been around all night and that's a little long
You think you got the right but I think you got it wrong
Oh, can't you say goodnight so you can take me home, Mickey?
'Cause when you say you will, it always means you won't
You're givin' me the chills, baby, please, baby, don't
Every night you still leave me all alone, Mickey
Oh, Mickey, what a pity you don't understand
You take me by the heart and you take me by the hand
Oh, Mickey, you're so pretty, can't you understand?
It's guys like you, Mickey
And what you do, Mickey, do, Mickey
Don't break my heart, Mickey
Hey, Mickey
Now if you take me by the, who's ever gonna know?
Every time you move, I let a little more show
There's something you can use so don't say no, Mickey
So come on and give it to me anyway you can
Anyway you wanna do it, I'll take it like a man
Oh, please, baby, please, don't leave me in the damn, Mickey
Oh, Mickey, what a pity you don't understand
You take me by the heart and you take me by the hand
Oh, Mickey, you're so pretty, can't you understand?
It's guys like you, Mickey
And what you do, Mickey, do, Mickey
Don't break my heart, Mickey
Oh, Mickey, what a pity you don't understand
You take me by the heart and you take me by the hand
Oh, Mickey, you're so pretty, can't you understand?
It's guys like you, Mickey
And what you do, Mickey, do, Mickey
Don't break my heart, Mickey
Oh, Mickey, you're so fine
You're so fine, you blow my mind
Hey, Mickey, hey, Mickey
Oh, Mickey, you're so fine
You're so fine, you blow my mind
Hey, Mickey, hey, Mickey
Oh, Mickey, you're so fine
You're so fine, you blow my mind
Hey, Mickey
Oh, Mickey, what a pity you don't understand
You take me by the heart and you take me by the hand
Oh, Mickey, you're so pretty, can't you understand?
It's guys like you, Mickey
And what you do, Mickey, do, Mickey
Don't break my heart, Mickey
Oh, Mickey, what a pity you don't understand
You take me by the heart and you take me by the hand
Oh, Mickey, you're so pretty, can't you understand?
It's guys like you, Mickey
And what you do, Mickey, do, Mickey
Don't break my heart, Mickey
Oh, Mickey, you're so fine
You're so fine, you blow my mind
Hey, Mickey, hey, Mickey
Oh, Mickey, you're so fine
You're so fine, you blow my mind