MHC class II
MHC (major histocompatibility complex) class II molecules are a family of molecules normally found only on antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells.
The antigens presented by class II peptides are derived from extracellular proteins (not cytosolic as in class I); hence, the MHC class II-dependent pathway of antigen presentation is called the endocytic or exogenous pathway.
Loading of a MHC class II molecule occurs by phagocytosis; extracellular proteins are endocytosed, digested in lysosomes, and the resulting epitopic peptide fragments are loaded onto MHC class II molecules prior to their migration to the cell surface.
Structure
Like MHC class I molecules, class II molecules are also heterodimers, but in this case consist of two homogenous peptides, an α and β chain, both of which are encoded in the MHC. The subdesignation α1, α2, etc. refers to separate domains within the HLA gene; each domain is usually encoded by a different exon within the gene, and some genes have further domains that encode leader sequences, transmembrane sequences, etc.
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Baby Won't Ya
by: MC5Oh come on, it's all over, over here
I sat up here in my window lookin' down on the street
A strychnine poison woman, man don't you look so sweet
Well I said come on up and see me sometime
I'm just a drunken sailor but I'm feelin' so fine
I've been out sailin' on the seven seas, baby won't you give it to me? Oh
Baby won't ya drive me mad? Baby don't ya let me feel bad
Baby don't ya leave me alone, baby won't ya carry me home?
Baby won't ya jump and shout? You know what I'm talkin' about
Baby won't ya drive me wild? Baby let me see you smile
Watching you, it's alright now
For now I see all the sickly, salty swingers standin' on a bathroom floor
Slidin' and glidin' as she passed by my window
She was a female mercenary comin' home from war
The ultimate inflection of the word perfection
I thought I'd drop by to say, "Hi"
Sweetly, serenely, she showed me her gun, baby let's go get high, oh
Baby won't ya drive me wild? Baby let me see you smile
Baby won't ya please come here? Baby don't ya have no fear
Baby won't ya scratch my back? Baby don't ya leave me mad
Baby won't ya drive me mad? Baby don't ya let me be mad
Come on, get down
Oh yeah yeah yeah yeah, well, come on now
I sat down to the matters at hand, tryin' to find a way to beat the heat
Outside my window was a bunch of tipsy gypsys
Dancin' up and down the street
The lovely senorita took me by my hand
She said, "Oh, baby won't you be my man?"
I'll get yours and you'll get mine, baby let's have a good time
Baby won't ya drive me mad? Baby don't ya let me feel bad
Baby don't ya leave me alone, baby won't ya carry me home?
Baby won't ya jump and shout? You know what I'm talking about
Baby won't ya drive me wild? Baby let me see you smile
Baby won't ya please come here? Baby don't ya have no fear
Baby let me hold your hand, baby let me be your man
Baby won't ya scratch my back? Baby don't ya leave me mad
Baby won't you [Incomprehensible], baby won't you [Incomprehensible]
Baby won't ya drive me mad? Baby don't ya let me feel bad
Baby don't ya leave me alone, baby won't ya carry me home?
Baby won't ya jump and shout? You know what I'm talkin' about
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