MHC class I
MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the body. Their function is to display fragments of non-self proteins from within the cell to cytotoxic T cells; this will trigger an immediate response from the immune system against the particular non-self antigen displayed with the help of MHC class I protein. Because MHC class I molecules present peptides derived from cytosolic proteins, the pathway of MHC class I presentation is often called the cytosolic or endogenous pathway.
Function
Class I MHC molecules bind peptides generated mainly from degradation of cytosolic proteins by the proteasome. The MHC I:peptide complex is then inserted into the plasma membrane of the cell. The peptide is bound to the extracellular part of the class I MHC molecule. Thus, the function of the class I MHC is to display intracellular proteins to cytotoxic T cells (CTLs). However, class I MHC can also present peptides generated from exogenous proteins, in a process known as cross-presentation.
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Baby Won't Ya
by: MC5Oh come on, it's all over, over here
I sat up here in my window lookin' down on the street
A strychnine poison woman, man don't you look so sweet
Well I said come on up and see me sometime
I'm just a drunken sailor but I'm feelin' so fine
I've been out sailin' on the seven seas, baby won't you give it to me? Oh
Baby won't ya drive me mad? Baby don't ya let me feel bad
Baby don't ya leave me alone, baby won't ya carry me home?
Baby won't ya jump and shout? You know what I'm talkin' about
Baby won't ya drive me wild? Baby let me see you smile
Watching you, it's alright now
For now I see all the sickly, salty swingers standin' on a bathroom floor
Slidin' and glidin' as she passed by my window
She was a female mercenary comin' home from war
The ultimate inflection of the word perfection
I thought I'd drop by to say, "Hi"
Sweetly, serenely, she showed me her gun, baby let's go get high, oh
Baby won't ya drive me wild? Baby let me see you smile
Baby won't ya please come here? Baby don't ya have no fear
Baby won't ya scratch my back? Baby don't ya leave me mad
Baby won't ya drive me mad? Baby don't ya let me be mad
Come on, get down
Oh yeah yeah yeah yeah, well, come on now
I sat down to the matters at hand, tryin' to find a way to beat the heat
Outside my window was a bunch of tipsy gypsys
Dancin' up and down the street
The lovely senorita took me by my hand
She said, "Oh, baby won't you be my man?"
I'll get yours and you'll get mine, baby let's have a good time
Baby won't ya drive me mad? Baby don't ya let me feel bad
Baby don't ya leave me alone, baby won't ya carry me home?
Baby won't ya jump and shout? You know what I'm talking about
Baby won't ya drive me wild? Baby let me see you smile
Baby won't ya please come here? Baby don't ya have no fear
Baby let me hold your hand, baby let me be your man
Baby won't ya scratch my back? Baby don't ya leave me mad
Baby won't you [Incomprehensible], baby won't you [Incomprehensible]
Baby won't ya drive me mad? Baby don't ya let me feel bad
Baby don't ya leave me alone, baby won't ya carry me home?
Baby won't ya jump and shout? You know what I'm talkin' about
Latest News for: mhc i
MHC’s Classic Rock Jam FUNdraiser is May 10
Marietta Daily Journal
13 Mar 2025
Federal Reserve Board announces termination of enforcement action with Lake Shore MHC and Lake Shore Bancorp Inc. (Board of Governors of the Federal Reserve System)
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