MEG3
MEG3 (maternally expressed 3) is a maternally expressed, imprinted long non-coding RNA gene. At least 12 different isoforms of MEG3 are generated by alternative splicing. Expression of MEG3 is lost in cancer cells. It acts as a growth suppressor in tumour cells, and activates p53. A pituitary transcript variant has been associated with inhibited cell proliferation. Studies in mouse and sheep suggest that an upstream intergenic differentially methylated region (IG-DMR) regulates imprinting of the region. The expression profile in mouse of the co-regulated Meg3 and Dlk1 genes suggests a causative role in the pathologies found in uniparental disomy animals, characterized by defects in skeletal muscle maturation, bone formation, placenta size and organization and prenatal lethality. The sheep homolog is associated with the callipyge mutation which in heterozygous individuals affects a muscle-specific long-range control element located in the DLK1-GTL2 intergenic region and results in the callipyge muscular hypertrophy. The non-Mendelian inheritance pattern, known as polar overdominance, likely results from the combination of the cis-effect on the expression levels of genes in the DLK1-GTL2 imprinted domain, and trans interaction between the products of reciprocally imprinted genes.
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Baby Won't Ya
by: MC5Oh come on, it's all over, over here
I sat up here in my window lookin' down on the street
A strychnine poison woman, man don't you look so sweet
Well I said come on up and see me sometime
I'm just a drunken sailor but I'm feelin' so fine
I've been out sailin' on the seven seas, baby won't you give it to me? Oh
Baby won't ya drive me mad? Baby don't ya let me feel bad
Baby don't ya leave me alone, baby won't ya carry me home?
Baby won't ya jump and shout? You know what I'm talkin' about
Baby won't ya drive me wild? Baby let me see you smile
Watching you, it's alright now
For now I see all the sickly, salty swingers standin' on a bathroom floor
Slidin' and glidin' as she passed by my window
She was a female mercenary comin' home from war
The ultimate inflection of the word perfection
I thought I'd drop by to say, "Hi"
Sweetly, serenely, she showed me her gun, baby let's go get high, oh
Baby won't ya drive me wild? Baby let me see you smile
Baby won't ya please come here? Baby don't ya have no fear
Baby won't ya scratch my back? Baby don't ya leave me mad
Baby won't ya drive me mad? Baby don't ya let me be mad
Come on, get down
Oh yeah yeah yeah yeah, well, come on now
I sat down to the matters at hand, tryin' to find a way to beat the heat
Outside my window was a bunch of tipsy gypsys
Dancin' up and down the street
The lovely senorita took me by my hand
She said, "Oh, baby won't you be my man?"
I'll get yours and you'll get mine, baby let's have a good time
Baby won't ya drive me mad? Baby don't ya let me feel bad
Baby don't ya leave me alone, baby won't ya carry me home?
Baby won't ya jump and shout? You know what I'm talking about
Baby won't ya drive me wild? Baby let me see you smile
Baby won't ya please come here? Baby don't ya have no fear
Baby let me hold your hand, baby let me be your man
Baby won't ya scratch my back? Baby don't ya leave me mad
Baby won't you [Incomprehensible], baby won't you [Incomprehensible]
Baby won't ya drive me mad? Baby don't ya let me feel bad
Baby don't ya leave me alone, baby won't ya carry me home?
Baby won't ya jump and shout? You know what I'm talkin' about