MED12

Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae), also known as MED12, is a human gene found on the X chromosome.

Clinical significance

Mutations in MED12 are responsible for at least two different forms of X-linked dominant mental retardation, Lujan-Fryns syndrome and FG syndrome, as well as instances of prostate cancer.

Mutations in MED12 are associated to uterine leiomyomas and breast fibroepithelial tumors (e.g. fibroadenoma and phyllodes tumors).

Interactions

MED12 has been shown to interact with:

Calcitriol receptor,

Cyclin-dependent kinase 8

Estrogen receptor alpha,

Gli3, G9a, PPARGC1A,

MED26,

SOX9, and

Thyroid hormone receptor alpha.

References

External links

GeneReviews/NCBI/NIH/UW entry on MED12-Related Disorders

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/MED12

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