MDL Chime

MDL Chime is a free plugin used by web browsers to display the three-dimensional structures of molecules. It is part of the ISIS product line acquired by Symyx Technologies from scientific publisher Elsevier in October 2007. It is based on the RasMol code.

Chime is used by a wide range of biochemistry web sites for the visualization of macromolecules. Many of these sites are linked to the World Index of Molecular Visualization Resources MolVisIndex.Org. Chime was also used until 2006 at the Protein Data Bank to examine structures stored there.

Although available in 1996 in both Windows 95 and Mac OS versions for both Netscape and Internet Explorer browsers, development of Chime did not follow the move to Mac OS X for the Mac and support for Windows-based browsers other than Internet Explorer was limited (although it works well in Mozilla Firefox). One significant feature added in 1997 was the ability to display spectroscopic data in the form of the IUPAC JCAMP-DX protocols. Apart from this, most updates since then were for the installation package to follow the development of Windows and Internet Explorer.

Chime

Chime or chimes may refer to:

Musical instrument or tone

People

Chime (bell instrument)

A carillon-like instrument with fewer than 23 bells is called a chime.

American chimes usually have one to one and a half diatonic octaves. Many chimes are automated.

The first bell chime was created in 1487. Before 1900, chime bells typically lacked dynamic variation and the inner tuning (the mathematical balance of a bell's complex sound) required to permit the use of harmony. Since then, chime bells produced in Belgium, the Netherlands, England, and America have inner tuning and can produce fully harmonized music. Some towers in England hung for full circle change ringing chime by an Ellacombe apparatus.

Notable chimes

Macintosh startup

The Macintosh startup sequence behaviors include the startup chime, Happy Mac, Sad Mac and Chimes of Death.

Startup chime

The Macintosh startup chime is the single note or chord (depending on model type) played when an Apple Macintosh computer is turned on. The sound indicates that diagnostic tests run immediately at startup have found no hardware or fundamental software problems.

Mark Lentczner created the code for the arpeggiated chord used on the Macintosh II. Variations of this sound were used until Jim Reekes created the startup chime used for the Quadra 700 through the Quadra 800. Reekes said, "The startup sound was done in my home studio on a Korg Wavestation. It's a C major chord, played with both hands stretched out as wide as possible (with 3rd at the top, if I recall)." He was also the creator of the iconic (or "earconic", as he calls it) "bong" startup chime used in most Macintoshes since the Quadra 840AV. A slightly lower-pitched version of this chime was used on all PCI-based Power Macs until the iMac G3. The Macintosh LC, LC II, and Macintosh Classic II do not use the Reekes chime, instead using an F major chord that just produces a "ding" sound. The first generation of Power Macintosh computers also do not use the Reekes chime, instead using a chord strummed on a Yamaha 12-string acoustic guitar by jazz guitarist Stanley Jordan. Further, the Power Macintosh 5200–6300 computers (excluding the 5400 and 5500, which still had the "bong" chime) used an exclusive chime not used on any other Macintosh model, and the 20th Anniversary Macintosh also used a special startup chime as well, exclusive to this particular Macintosh.

MDL

MDL may mean:

MDL (programming language)

MDL (the MIT Design Language) is a descendant of the Lisp programming language. Its initial purpose was to provide high level language support for the Dynamic Modeling Group at MIT's Project MAC. It was initially developed in 1971 on the PDP-10 computer under the Incompatible Timesharing System. The initial development team consisted of Gerald Sussman and Carl Hewitt of the Artificial Intelligence Lab, and Chris Reeve, Bruce Daniels, and David Cressey of the Dynamic Modeling Group. Later, Stu Galley, also of the Dynamic Modeling Group, wrote the MDL documentation.

MDL was initially known as “Muddle”. This style of self-deprecating humor was not widely understood or appreciated outside of Project MAC and a few other early citadels of information technology. So the name was sanitized to MDL.

MDL provides several enhancements to classical Lisp. It supports several built-in data types, including lists, strings and arrays, and user-defined data types. It offers multithreaded expression evaluation and coroutines. Variables can carry both a local value within a scope, and a global value, for passing data between scopes. Advanced built-in functions supported interactive debugging of MDL programs, incremental development, and reconstruction of source programs from object programs.

Suritozole

Suritozole (MDL 26,479) is an investigational cognition enhancer. It acts as a partial inverse agonist at the benzodiazepine receptor site on the GABA_A ion channel complex, but does not have either anxiogenic or convulsant effects, unlike other BZD inverse agonists such as DMCM. It was investigated for the treatment of depression and Alzheimer's disease, but clinical development seems to have been discontinued.

References