MDAI
5,6-Methylenedioxy-2-aminoindane (MDAI) is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a non-neurotoxic and highly selective serotonin releasing agent (SSRA) in vitro and produces entactogen effects in humans.
Chemistry
The chemical structure of MDAI is indirectly derived from that of the illicit drug MDA, but the alpha-methyl group of the alkyl amino amphetamine side chain has been bound back to the benzene nucleus to form an indane ring system, which changes its pharmacological properties substantially.
MDAI can be produced from 3-(3,4-Methylenedioxyphenyl)propionic acid which is converted to the acid chloride and then heated to produce 5,6-Methylenedioxy-1-indanone. Treatment of the indanone with amyl nitrite in methanol with HC1 afforded the hydroxyimino ketone. This is reduced to the 2-aminoindan following a modification of Nichols' earlier method from a paper discussing DOM analogues, using a Pd/C catalyst in glacial acetic acid with catalytic H2SO4.
Podcasts:
-
by M.O.D.
-
by M.O.D.
-
by M.O.D.
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
-
by 98 Mute
Imported Society
by: M.O.D.They came from the other side
In bunches at a time
Crowding up the neighborhood
To raise the rates of crime
Some of them got money
Most of them got shit
All they do is come here
To take from our pockets
Import, import, imported society
Import, import, imported society
Import, import, imported society
Import, import, imported society
Don't you fucking see
That you bother me
Genocide
You can't hide
So go home now
Don't come back
Take your goat
Get on your boat
I hate imports
I don't want to hear their shit
I hate imports
Cause I'm just so sick of it
I just want to
Live my life without you fucking assholes
And I want to
Never see your ass again
Import, import, imported society
Import, import, imported society
Import, import, imported society
Import, import, imported society
Hindus and Ethiopians
You know they're all the same
A huck a buck of Indians