MDA5 (Melanoma Differentiation-Associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the IFIH1 gene. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor (recognizing dsRNA) that is a sensor for viruses. MDA5 typically recognizes dsRNA that is over 2000nts in length. For many viruses, effective MDA5-mediated antiviral responses are dependent on functionally active LGP2. The signaling cascades in MDA5 is initiated via CARD domain.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.
They came from the other side
In bunches at a time
Crowding up the neighborhood
To raise the rates of crime
Some of them got money
Most of them got shit
All they do is come here
To take from our pockets
Import, import, imported society
Import, import, imported society
Import, import, imported society
Import, import, imported society
Don't you fucking see
That you bother me
Genocide
You can't hide
So go home now
Don't come back
Take your goat
Get on your boat
I hate imports
I don't want to hear their shit
I hate imports
Cause I'm just so sick of it
I just want to
Live my life without you fucking assholes
And I want to
Never see your ass again
Import, import, imported society
Import, import, imported society
Import, import, imported society
Import, import, imported society
Hindus and Ethiopians
You know they're all the same
A huck a buck of Indians