MCM7

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Interactions

MCM7 has been shown to interact with:

PABCO Transit

PABCO Transit, Inc., (now NJ Transit Morris, Inc.) doing business under the Morris County Metro brand, was a public transport company based in Dover, New Jersey operating local bus service in Morris County for New Jersey Transit. The company was originally called Passaic - Athena Bus Lines which operated service in Passaic and Clifton, New Jersey.

Passaic-Athenia Bus Co.

The Passaic-Athenia Bus Co. (originally Red Star Transportation up until 1922) operated the following routes prior to NJ Transit's takeover and contracting of the routes. The 702 was co-operated with Garfield & Passaic Transit as their #6 route and Community as its #1 route.

Morris County Metro

Renumbered routes

In October 2010, New Jersey Transit decided to take over these routes and split them into routes 871–875 and 880 by a newly created subsidiary called NJ Transit Morris, Inc. Morris County still subsidizes their operation. These routes are part of the Central Division.

Previously discontinued routes

On June 1, 2010 New Jersey Transit has decided to stop subsidizing the following routes leading to their discontinuation at the end of June.