ACTH receptor
The adrenocorticotropic hormone receptor or ACTH receptor also known as the melanocortin receptor 2 or MC2 receptor is a type of melanocortin receptor (type 2) which is specific for ACTH.
Structure
Both human and bovine ACTH receptors are synthesized as 297 residue long proteins. There is 81% homology between human and bovine sequences. The full length sequence includes seven hydrophobic domains that are predicted as transmembrane segments. In the third intracellular loop of the receptor a protein kinase A and protein kinase c phosphorylation motifs have been detected.
Tissue and subcellular localization
ACTH receptor is found in the zona fasciculata of the human adrenal cortex. Binding of the receptor by ACTH stimulates the production of cortisol. (By contrast, aldosterone production from the zona glomerulosa is stimulated primarily by angiotensin II.)
Protein recognition at the receptor uses energy obtained from the dephosphorylation of ATP to cAMP by adenylate cyclase. ACTH receptors are located on the plasma membrane, and are G protein-coupled receptors.
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by Micocaro
Things That Bend
by: MicocaroGoing to the city........
Run to the city with your own contraption
Run to the city for a new reaction
To the city for your own advantage
To the city for a sidewalk attraction
Hmm.......
See the light that you hold now in our times
Sole single light
Sole single light
See the light that you hold out in our times
Sole single light
Sole single light
So, get ready for what the lights intended
Stay in the city for the love of attention
In the city that is most intensive
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Up for the looks and the outboasts
Side street crowds and the kids on the lampposts
Catch a glimpse of the light from the street show
Hopes there'll be a sign
See the light that you hold now in our times
Sole single light
Sole single light
See the light that you hold out in our times
Sole single light
Sole single light
So, get ready for what the lights intended
Stay in the city for the love of attention
In the city that is most inventive
In the city where the light will protect you now