Mat1

Menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)

PDB rendering based on 1g25.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1G25

Identifiers

Symbols

MNAT1; CAP35; MAT1; RNF66; TFB3

External IDs

OMIM: 602659 MGI: 106207 HomoloGene: 1821 ChEMBL: 5053 GeneCards: MNAT1 Gene

Gene Ontology
Molecular function	• protein kinase activity • protein binding • DNA-dependent ATPase activity • zinc ion binding • RNA polymerase II carboxy-terminal domain kinase activity • metal ion binding • protein N-terminus binding
Cellular component	• nucleus • nucleoplasm • holo TFIIH complex • cytoplasm • intracellular membrane-bounded organelle
Biological process	• regulation of cyclin-dependent protein kinase activity • G1 phase of mitotic cell cycle • G1/S transition of mitotic cell cycle • S phase of mitotic cell cycle • G2/M transition of mitotic cell cycle • mitotic cell cycle • nucleotide-excision repair, DNA damage removal • DNA repair • transcription-coupled nucleotide-excision repair • nucleotide-excision repair • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase I promoter • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase I promoter • termination of RNA polymerase I transcription • transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • mRNA capping • protein complex assembly • protein phosphorylation • adult heart development • cell proliferation • gene expression • viral reproduction • ventricular system development • negative regulation of apoptotic process • multicellular organismal metabolic process • positive regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • positive regulation of smooth muscle cell proliferation • positive regulation of viral transcription • regulation of catalytic activity • response to calcium ion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
61.2 – 61.44 Mb

Chr 12:
74.22 – 74.37 Mb

PubMed search

[1]

[2]

CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene.^[1]

Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'menage a trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM]^[2]

Interactions [link]

MNAT1 has been shown to interact with POU2F1,^[3] MTA1,^[4] Cyclin H,^[4]^[5] P53,^[6] Estrogen receptor alpha,^[4] MCM7^[7] and Cyclin-dependent kinase 7.^[4]^[8]

References [link]

^ Eki T, Okumura K, Abe M, Kagotani K, Taguchi H, Murakami Y, Pan ZQ, Hanaoka F (April 1998). "Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively". Genomics 47 (1): 115–20. DOI:10.1006/geno.1997.5053. PMID 9465303.
^ "Entrez Gene: MNAT1 menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4331.
^ Inamoto, S; Segil N, Pan Z Q, Kimura M, Roeder R G (November 1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. (UNITED STATES) 272 (47): 29852–8. DOI:10.1074/jbc.272.47.29852. ISSN 0021-9258. PMID 9368058.
^ ^a ^b ^c ^d Talukder, Amjad H; Mishra Sandip K, Mandal Mahitosh, Balasenthil Seetharaman, Mehta Sonal, Sahin Aysegul A, Barnes Christopher J, Kumar Rakesh (March 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". J. Biol. Chem. (United States) 278 (13): 11676–85. DOI:10.1074/jbc.M209570200. ISSN 0021-9258. PMID 12527756.
^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
^ Ko, L J; Shieh S Y, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan Z Q (December 1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner". Mol. Cell. Biol. (UNITED STATES) 17 (12): 7220–9. ISSN 0270-7306. PMC 232579. PMID 9372954. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232579.
^ Wang, Y; Xu F, Hall F L (October 2000). "The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor". FEBS Lett. (NETHERLANDS) 484 (1): 17–21. DOI:10.1016/S0014-5793(00)02117-7. ISSN 0014-5793. PMID 11056214.
^ Yee, A; Nichols M A, Wu L, Hall F L, Kobayashi R, Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. (UNITED STATES) 55 (24): 6058–62. ISSN 0008-5472. PMID 8521393.

Further reading [link]

Jeang KT (1998). "Tat, Tat-associated kinase, and transcription.". J. Biomed. Sci. 5 (1): 24–7. DOI:10.1007/BF02253352. PMID 9570510.
Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation.". Curr. Biol. 8 (13): R447–9. DOI:10.1016/S0960-9822(98)70289-1. PMID 9651670.
Le Goff P, Montano MM, Schodin DJ, Katzenellenbogen BS (1994). "Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.". J. Biol. Chem. 269 (6): 4458–66. PMID 8308015.
Yee A, Nichols MA, Wu L, et al. (1996). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor.". Cancer Res. 55 (24): 6058–62. PMID 8521393.
Tassan JP, Jaquenoud M, Fry AM, et al. (1996). "In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.". EMBO J. 14 (22): 5608–17. PMC 394676. PMID 8521818. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=394676.
Blau J, Xiao H, McCracken S, et al. (1996). "Three functional classes of transcriptional activation domain.". Mol. Cell. Biol. 16 (5): 2044–55. PMC 231191. PMID 8628270. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231191.
Reardon JT, Ge H, Gibbs E, et al. (1996). "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6482–7. DOI:10.1073/pnas.93.13.6482. PMC 39049. PMID 8692841. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39049.
Drapkin R, Le Roy G, Cho H, et al. (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. DOI:10.1073/pnas.93.13.6488. PMC 39050. PMID 8692842. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39050.
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.". Science 274 (5287): 605–10. DOI:10.1126/science.274.5287.605. PMID 8849451.
Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain.". Nature 384 (6607): 375–8. DOI:10.1038/384375a0. PMID 8934526.
García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.". J. Biol. Chem. 272 (11): 6951–8. DOI:10.1074/jbc.272.11.6951. PMID 9054383.
Marinoni JC, Roy R, Vermeulen W, et al. (1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.". EMBO J. 16 (5): 1093–102. DOI:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169708.
Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028. PMID 9121429. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232028.
Rossignol M, Kolb-Cheynel I, Egly JM (1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH.". EMBO J. 16 (7): 1628–37. DOI:10.1093/emboj/16.7.1628. PMC 1169767. PMID 9130708. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169767.
García-Martínez LF, Mavankal G, Neveu JM, et al. (1997). "Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription.". EMBO J. 16 (10): 2836–50. DOI:10.1093/emboj/16.10.2836. PMC 1169892. PMID 9184228. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169892.
Nekhai S, Shukla RR, Kumar A (1997). "A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity.". J. Virol. 71 (10): 7436–41. PMC 192089. PMID 9311822. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=192089.
Cujec TP, Okamoto H, Fujinaga K, et al. (1997). "The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II.". Genes Dev. 11 (20): 2645–57. DOI:10.1101/gad.11.20.2645. PMC 316603. PMID 9334327. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316603.
Inamoto S, Segil N, Pan ZQ, et al. (1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors.". J. Biol. Chem. 272 (47): 29852–8. DOI:10.1074/jbc.272.47.29852. PMID 9368058.
Ko LJ, Shieh SY, Chen X, et al. (1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.". Mol. Cell. Biol. 17 (12): 7220–9. PMC 232579. PMID 9372954. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232579.

PDB gallery

1g25: SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THE HUMAN TFIIH MAT1 SUBUNIT

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Kiss my tired head.
And each letter written wastes your hand, young man
Come and lead me to your bed
You gave me hope that I'd not lost her
And then thought it rather strange to see me smile-
as I don't do too much smiling these days.
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"I must confess, I'm glad to see it go."
We're two white roses lying frozen just outside his door
I've made you so happy and so sad,
But which should I be more sorry for?
Come kiss my face goodbye,
that space below my eye and above my cheek
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And I shall be released.
I'll pass like a fever from this body,
And softly slip into his hands
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Interactions [link]

References [link]

Further reading [link]

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