MAS1

MAS proto-oncogene, or mas-related G-protein coupled receptor A (MRGA, MRGPRA, MRGPCRA), also proposed as the adenine receptor or P0 receptor, is a protein that in humans is encoded by the MAS1 gene.

The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.

Agonists of the receptor include adenine and 8-aminoadenine.

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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.