MAFK
Transcription factor MafK is a protein that in humans is encoded by the MAFK gene.
The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 177000). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM]
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Podcasts:
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by Pearl Jam
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by Redman
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by Die Fantastischen Vier
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by Hawkeye
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by Future
MFC
by: Pearl JamSliding out of reverse into drive, this
We will be turning right, then straight
Off in the sunset she'll ride
She can remember a time denied
Stood by the side of the road, spilled like wine now
She's out on her own and I'm high
There's no leaving here
Ask- I'm an ear
She's disappeared
They said that timing was everything
Made him want to be everywhere
There's a lot to be said for nowhere
There's no leaving here
Ask- I'm an ear
He's disappeared
There's no leaving here
Ask- I'm an ear
Fuck it- we've disappeared