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MAP-kinase activating death domain

Identifiers

Symbols

MADD; DENN; IG20; RAB3GEP

External IDs

OMIM: 603584 MGI: 2444672 HomoloGene: 14249 GeneCards: MADD Gene

Gene Ontology
Molecular function	• guanyl-nucleotide exchange factor activity • death receptor binding • protein binding • Rab guanyl-nucleotide exchange factor activity • protein kinase activator activity
Cellular component	• cytoplasm • plasma membrane • integral to membrane
Biological process	• activation of MAPK activity • positive regulation of protein phosphorylation • cell surface receptor signaling pathway • regulation of apoptotic process • regulation of cell cycle
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
47.29 – 47.36 Mb

Chr 2:
90.98 – 91.02 Mb

PubMed search

[1]

[2]

MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene.^[1]^[2]^[3]

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.^[3]

References [link]

^ Schievella AR, Chen JH, Graham JR, Lin LL (Jun 1997). "MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase". J Biol Chem 272 (18): 12069–75. DOI:10.1074/jbc.272.18.12069. PMID 9115275.
^ Chow VT, Lim KM, Lim D (Nov 1998). "The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22". Genome 41 (4): 543–52. DOI:10.1139/gen-41-4-543. PMID 9796103.
^ ^a ^b "Entrez Gene: MADD MAP-kinase activating death domain". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8567.

Further reading [link]

Chow VT, Lee SS (1997). "DENN, a novel human gene differentially expressed in normal and neoplastic cells". DNA Seq. 6 (5): 263–73. DOI:10.3109/10425179609020873. PMID 8988362.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. DOI:10.1093/dnares/4.2.141. PMID 9205841.
Zhang Y, Zhou L, Miller CA (1998). "A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2586–91. DOI:10.1073/pnas.95.5.2586. PMC 19423. PMID 9482930. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19423.
Suzuki Y, Ishihara D, Sasaki M, et al. (2000). "Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries". Genomics 64 (3): 286–97. DOI:10.1006/geno.2000.6076. PMID 10756096.
Telliez JB, Bean KM, Lin LL (2000). "LRDD, a novel leucine rich repeat and death domain containing protein". Biochim. Biophys. Acta 1478 (2): 280–8. DOI:10.1016/S0167-4838(00)00029-7. PMID 10825539.
Iwasaki K, Toyonaga R (2000). "The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission". EMBO J. 19 (17): 4806–16. DOI:10.1093/emboj/19.17.4806. PMC 302062. PMID 10970871. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=302062.
Al-Zoubi AM, Efimova EV, Kaithamana S, et al. (2002). "Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3". J. Biol. Chem. 276 (50): 47202–11. DOI:10.1074/jbc.M104835200. PMID 11577081.
Lim KM, Chow VT (2002). "Induction of marked apoptosis in mammalian cancer cell lines by antisense DNA treatment to abolish expression of DENN (differentially expressed in normal and neoplastic cells)". Mol. Carcinog. 35 (3): 110–26. DOI:10.1002/mc.10082. PMID 12410563.
Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. DOI:10.1101/gr.406902. PMC 187542. PMID 12421765. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187542.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Efimova E, Martinez O, Lokshin A, et al. (2004). "IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth". Cancer Res. 63 (24): 8768–76. PMID 14695193.
Efimova EV, Al-Zoubi AM, Martinez O, et al. (2004). "IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs". Oncogene 23 (5): 1076–87. DOI:10.1038/sj.onc.1207210. PMID 14716293.
Lim KM, Yeo WS, Chow VT (2004). "Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle". Int. J. Cancer 109 (1): 24–37. DOI:10.1002/ijc.11660. PMID 14735464.
Del Villar K, Miller CA (2004). "Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons". Proc. Natl. Acad. Sci. U.S.A. 101 (12): 4210–5. DOI:10.1073/pnas.0307349101. PMC 384720. PMID 15007167. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=384720.
Xu Y, Kulkosky J, Acheampong E, et al. (2004). "HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 7070–5. DOI:10.1073/pnas.0304859101. PMC 406467. PMID 15103018. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=406467.
Ramaswamy M, Efimova EV, Martinez O, et al. (2005). "IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC". Oncogene 23 (36): 6083–94. DOI:10.1038/sj.onc.1207804. PMID 15208670.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Hu YF, Zhang HL, Cai T, et al. (2006). "The IA-2 interactome". Diabetologia 48 (12): 2576–81. DOI:10.1007/s00125-005-0037-y. PMID 16273344.

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MADD

MADD may refer to:

Mothers Against Drunk Driving

Myoadenylate deaminase deficiency, a metabolic disorder also called Adenosine monophosphate deaminase deficiency type 1

Multiple acyl-CoA dehydrogenation deficiency, another name for the genetic disorder Glutaric acidemia type 2

MAP kinase-activating death domain protein

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/MADD

Gene

A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.

Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term "having a gene" (e.g., "good genes," "hair colour gene") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Gene

Eugene (given name)

Eugene is a common (masculine) first name that comes from the Greek εὐγενής (eugenēs), "noble", literally "well-born", from εὖ (eu), "well" and γένος (genos), "race, stock, kin".Gene is a common shortened form. The feminine variant is Eugenia or Eugénie.

Male foreign-language variants include:

Notable people

Christianity

Pope Eugene I, pope from 655 to 657

Pope Eugene II, pope from 824 to 827

Pope Eugene III, pope from 1145 to 1153

Pope Eugene IV, pope from 1431 to 1447

Charles-Joseph-Eugene de Mazenod (1782–1861), the founder of the Missionary Oblates of Mary Immaculate

St. Eugene, one of the deacons of Saint Zenobius

Saint Eugenios of Trebizond was the patron saint of the Empire of Trebizond

Pope Pius XII, pope from 1939 to 1958, given name Eugenio Maria Giuseppe Giovanni Pacelli

Eugene Antonio Marino (1934–2000), first African-American archbishop in the United States

Eugênio de Araújo Sales (1920–2012), Roman Catholic cardinal from Brazil

Military

Eugène de Beauharnais (1781–1824), the stepson and adopted child of Napoleon

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Eugene_(given_name)

Gene (novel)

Gene is a thriller novel by Stel Pavlou (born 1970), published in 2005 in England by Simon & Schuster. It is published in several languages with some title changes. The Italian edition has the title La Conspirazione del Minotauro (The Minotaur Conspiracy). The novel is about a fictional New York detective, James North, who in the process of hunting down a criminal, uncovers a genetics experiment to unlock past lives through genetic memory, therefore achieving a kind of immortality. In so doing North discovers his own origins, that of a soldier from the Trojan War who is reincarnated seven times through history, forced to confront his nemesis each time, all for the loss of his one true love.

Characters

Cyclades (born circa 1300 BC)

Incarnations of Cyclades

Detective James North (2004 AD)

Eugene Dybbuk (2004 AD)

Aquilo (75 AD)

Aisha (2004)

William Porter (2004)

Athanatos (born circa 1500 BC)

Incarnations of Athanatos