LYN

Tyrosine-protein kinase Lyn is a protein that in humans is encoded in humans by the LYN gene.

Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. In various hematopoietic cells, Lyn has emerged as a key enzyme involved in the regulation of cell activation. In these cells, a small amount of LYN is associated with cell surface receptor proteins, including the B cell antigen receptor (BCR),CD40, or CD19. The abbreviation Lyn is derived from Lck/Yes novel tyrosine kinase, Lck and Yes also being members of the Src kinase family.

Function

Lyn has been described to have an inhibitory role in myeloid lineage proliferation. Following engagement of the B cell receptors, Lyn undergoes rapid phosphorylation and activation. LYN activation triggers a cascade of signaling events mediated by Lyn phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the receptor proteins, and subsequent recruitment and activation of other kinases including Syk, phosholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase. These kinases provide activation signals, which play critical roles in proliferation, Ca²⁺ mobilization and cell differentiation. Lyn plays an essential role in the transmission of inhibitory signals through phosphorylation of tyrosine residues within the immunoreceptor tyrosine-based inhibitory motifs (ITIM) in regulatory proteins such as CD22, PIR-B and FCγRIIb1. Their ITIM phosphorylation subsequently leads to recruitment and activation of phosphatases such as SHIP-1 and SHP-1, which further downmodulate signaling pathways, attenuate cell activation and can mediate tolerance. In B cells, Lyn sets the threshold of cell signaling and maintains the balance between activation and inhibition. Lyn thus functions as a rheostat that modulates signaling rather than as a binary on-off switch.

Lyn (singer)

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Lee Se-jin (born on Seoul, South Korea on 9 November 1981) is a South Korean R&B singer known professionally as Lyn. She has released ten full albums to date.

Biography

Lyn was born in Seoul, South Korea on 9 November 1981. She graduated from Seoul High School and attended University of Seoul.

Career

Lyn was first scouted by an agency because of her voice and from there, she first made her debut under her real name, Lee Se-jin, and released an album. The album sold poorly and was barely known. Lyn then took some time off to train vocally. She made a comeback in 2002 under the name Lyn with her supposedly first album Have You Ever Have A Broken Heart?. It was very successful and was able to shoot her up to one of the top R&B female solo singer of the year. After a surprise two years hiatus, Lyn released her second album Can U See The Bright. The album was very successful, surpassing her previous album with her popular single, "사랑했잖아" (Used To Love). Due to its popularity, the song was eventually covered on another successful singer Lee Seung-gi's album, released in late 2006. Lyn released her third album, The Pride of the Morning, on March 7, 2007, and sold 15,358 copies in that month, placing second in the Music Industry Association of Korea's monthly chart. Again, it was a success and was once again reclaim her title as one of the best R&B female singer. Overall her album sold 25,171 copies. Lyn then released more albums afterwards, and did not become very successful, but in 2009 she made a comeback with her 5th album called 'Let Go, Let In, It's a New Day'. In early 2012, she released her 7th album title 'Love Fiction'.

Lynn (name)

Lynn or Lynne is a surname and given name in English speaking countries.

Surname

It has a number of separate derivations:

The earliest recorded instance of the surname is Aedricus de Lenna of King's Lynn (1177).

Given name

As a given name, Lynn is predominantly female. Now it is more popular as a middle name than as a first name. It is also popular as a suffix for female first names, such as Madalyn/Madalynn, Jocelyn/Jocelynn, Ashlyn/Ashlynn and Emmalyn/Emmalynn. In the year 2013, only 90 girls were given the name Lynn in the United States (variant spellings not included), according to Social Security's "Beyond The Top 1000" name lists, available for download on their website.

Implode (album)

Implode is an album by industrial group Front Line Assembly. The album was released through Metropolis on April 26, 1999.

Release

Implode was released on digipak CD and via Zoth Ommog on gatefold cover sleeve double vinyl with limited circulation of 2,000. The track "Torched" is featured in the 2002 horror film Resident Evil but not on the accompanying soundtrack.

Singles

Implode was followed by the release of two singles. The single Prophecy includes the original version, a radio edit and a remix of the title track. "Unknown Dreams" is also featured as radio edit. "Paralysis" is a non-album track. The second single, Fatalist, was released in different versions in Europe and North America. German label Zoth Ommog issued a four-track single that contains remixes of "Fatalist" (Rhys Fulber), "Retribution" (Front 242) and "Prophecy" (Haujobb) as well as non-album track "Deception". The six track version was released for the Scandinavian countries through Energy and in the United States through Metropolis. Additional tracks on this version are two remixes of "Fatalist" by Aqualite and Tribal Techno.

Hogwarts staff

The following fictional characters are staff members and denizens of Hogwarts in the Harry Potter books written by J. K. Rowling.

The staff and their positions

Notable teachers and staff members

The following are notable teachers and staff members who do not have their own articles or who are not listed in other articles.

Argus Filch

Argus Filch is the caretaker of Hogwarts. While he is not an evil character, he is ill-tempered, which makes him unpopular with the student body, and occasionally with other staff. His knowledge of the secrets and short-cuts of the castle is almost unparalleled, except perhaps by the Weasley twins, Voldemort himself, Harry, Ron and Hermione, and other users of the Marauder's Map. He tends to favour almost sadistically harsh punishments, leading to his alliance with Dolores Umbridge. He has an obsessive dislike of mud, animate toys, and all other things that might interfere with his creation of an immaculately clean and orderly Hogwarts. He is also portrayed as having a constant antagonism towards Peeves the poltergeist and often tells Dumbledore that Peeves should be thrown out of Hogwarts. He also likes to wander Hogwarts corridors at night, presumably in the hope of catching a student out of bed.

Prophecy (Albert Ayler album)

Prophecy is a live album by American free jazz saxophonist Albert Ayler recorded in New York City in 1964 and first released in 1975 on the ESP-Disk label.

Reception

The Allmusic review by Scott Yanow awarded the album 3 stars stating "Ayler alternated the simple march-like themes with wild and very free improvisations which owe little if anything to the bop tradition, or even his contemporaries in the avant-garde. Ayler always had his own individual message, and his ESP sessions find him in consistently explorative form".

All About Jazz noted "Though the trio had honed a group sound and method comprising slow and loping or extremely fast themes; Murray's constant percussive chatter and vocal wailing providing an alternate pure-sound springboard; Peacock's constant harmonic filigree creating yet another aural web, these are presented in Prophecy as a much looser framework".

Track listing

All compositions by Albert Ayler