KLRA1
Ly-49 receptors or killer cell lectin-like receptor subfamily A (KLRA), are a class of natural killer cell receptor. Ly-49 proteins are a diverse set of C-type lectins that are expressed on NK cells in some mammals, including rodents but not humans. Their primary function is to bind host MHC class I as a mechanism of self/health recognition. Upon binding ligands, most Ly-49 receptors will deliver an inhibitory signal, preventing killing of the target cell. In the case of cancer or virally infected cells, MHC-I will often be downregulated in order to limit cytotoxic T cell mediated killing of the cell, whereby NK cells will lack Ly-49 inhibitory signal and be able to kill infected or cancerous target cells.
The homologous human KLRAP1 gene has been classified as a transcribed pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD).
References
External links
Podcasts:
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by 3LW
-
by Law
-
by Law
-
by Law
-
by Law
-
by Law
-
by Law
-
by Law
-
by Law
-
by Law
-
by Law
-
by Law
-
by Law
-
by LO
Leave Wit You (I Think I Wanna)
by: 3LW[intro:]
uh-huh, uh-huh
uh-huh, uh-huh
[verse 1:]
lookin' familiar, i don't know,
have i seen you somewhere before,
kill the small talk let's hit the floor, (are you ready)
to do something you aint done before,
i'll work it 'til you can't take no more,
i think i'm the girl you came here for, (if you can't get it)
[hook:]
i like it
what your doin'
how your movin'
so keep it comin' boy put it on me
[chorus:]
i think i wanna leave wit you do you wanna leave wit me
tell me what you wanna do boy
oh-oh-oh
i think i wanna leave wit you do you wanna leave wit me tell me what you wanna do boy
(if you can't get it)
[verse 2:]
you're lookin' at me like you want more, so after the party let's explode, turn off the lights
and lock the door, (when we're ready) but we aint leavin' here 'til i'm full, freakin' eachother
'til we sore, think i'm the girl you came here for (if you can't get it)
[hook]
[chorus]