USS Ashland (LSD-1)

USS Ashland (LSD-1) was the lead ship of her class—indeed, the first dock landing ship of the United States Navy. She was the first Navy ship to be named for Ashland, the estate of Henry Clay, in Lexington, Kentucky.

Ashland was laid down on 22 June 1942 at Oakland, California, by the Moore Dry Dock Company; launched on 21 December 1942; sponsored by Mrs. Jabez Lowell, the wife of Captain Lowell who was then the inspector of naval material at San Francisco; and commissioned on 5 June 1943, Lieutenant Commander Francis J. Harris in command.

World War II

Following two months of trials, the dock landing ship loaded amphibious craft and personnel at San Diego, stood out to sea on 11 August, and headed west. After arriving at Pearl Harbor on 19 August, the ship paused to take on more cargo and sailed on 25 August for Baker Island. Ashland reached that destination on 1 September, unloaded her equipment, and returned to Hawaii on 27 September. Following voyage repairs, and the embarkation of Army troops, she sailed on 19 October for New Caledonia. At Nouméa, the ship loaded tanks and marines and proceeded to Efate where she joined Task Force 53 (TF 53) to take part in amphibious assault exercises in the Gilbert Islands area which she completed on 28 November and set a course for Hawaii. She arrived at Pearl Harbor on 7 December and then commenced an availability period for voyage repairs and alterations.

KDM1A

Lysine-specific histone demethylase 1A (KDM1A) also known as lysine (K)-specific demethylase 1A (LSD1) is a protein in humans that is encoded by the KDM1A gene. LSD1 is a flavin-dependent monoamine oxidase, which can demethylate mono- and di-methylated lysines, specifically histone 3, lysines 4 and 9 (H3K4 and H3K9). This enzyme can have roles critical in embryogenesis and tissue-specific differentiation, as well as oocyte growth. KDM1A was the first histone demethylase to be discovered though more than 30 have been described.

Structure

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase.

Function

LSD1 (lysine-specific demethylase 1), also known as KDM1, is the first of several protein lysine demethylases discovered. Through a FAD-dependent oxidative reaction, LSD1 specifically removes histone H3K4me2 to H3K4me1 or H3K4me0. When forming a complex with androgen receptor (and possibly other nuclear hormone receptors), LSD1 changes its substrates to H3K9me2. It's now known LSD1 complex mediates a coordinated histone modification switch through enzymatic activities as well as histone modification readers in the complex.

Oresteia

The Oresteia (Ancient Greek: Ὀρέστεια) is a trilogy of Greek tragedies written by Aeschylus concerning the end of the curse on the House of Atreus. The name derives from the character Orestes, who sets out to avenge his father's murder.

The only extant example of an ancient Greek theater trilogy, the Oresteia won first prize at the Dionysia festival in 458 BC. When originally performed, it was accompanied by Proteus, a satyr play that would have followed the trilogy. Proteus has not survived, however. In all likelihood the term "Oresteia" originally referred to all four plays; today it generally designates only the surviving trilogy.

Many consider the Oresteia to be Aeschylus' finest work. Principal themes of the trilogy include the contrast between revenge and justice, as well as the transition from personal vendetta to organized litigation.

Agamemnon

Introduction

The play Agamemnon (Ἀγαμέμνων, Agamemnōn) details the homecoming of Agamemnon, King of Argos, from the Trojan War. Waiting at home for him is his wife, Clytemnestra, who has been planning his murder, partly as revenge for the sacrifice of their daughter, Iphigenia, and partly because in the ten years of Agamemnon's absence Clytemnestra has entered into an adulterous relationship with Aegisthus, Agamemnon's cousin and the sole survivor of a dispossessed branch of the family (Agamemnon's father, Atreus, killed and fed Aegisthus's brothers to Aegisthus's father, Thyestes, when he took power from him), who is determined to regain the throne he believes should rightfully belong to him.

Proteus (Marvel Comics)

Kevin MacTaggert, best known as Proteus and also called Mutant X, is a Marvel Comics character, associated with the X-Men.

Kevin was the mutant son of Scottish genetic researcher Moira MacTaggert and politician Joseph MacTaggert. Kevin had reality warping and possession powers and lived most of his life in forced seclusion at his mother’s Muir Island research facility.

His attempt to break free and find his father made up a classic 1979–80 Uncanny X-Men storyline that was adapted in the 1990s X-Men animated series. In 2009, Proteus was ranked as IGN's 77th Greatest Villain of All Time.

Publication history

Created by writer Chris Claremont and artist/co-writer John Byrne, Proteus first appeared in Uncanny X-Men #125 (September 1979), though hints to his character appeared in earlier issues. First, he appears off-panel in Uncanny X-Men #104. His voice is then revealed in Uncanny X-Men #119, as he took over the body of his first victim off-panel.

Fictional character biography

Narrow gauge engines (Thomas & Friends)

In Thomas & Friends, the Island of Sodor is home to a narrow gauge railway in the hills. These lines and the engines who work on them are some of the oldest on the island. The narrow gauge railway has some contact with The Fat Controller's standard gauge engines, but the location of the railway leaves the little engines in relative isolation.

North Western Railway

Victor

Victor is a dark red Hispanic tank engine in charge of the Sodor Steamworks. He supervises all the engines who journey in and out of the workshops, as well as Kevin, the clumsy yard crane. Victor always has a helpful, constructive disposition and is good-humored with everyone he meets. He speaks with a Cuban accent and spoke Spanish when he first came to Sodor.

Victor was introduced in the feature-length special Hero of the Rails. The show's staff were researching real-life engine workshops as inspiration for the Steamworks when they learned that one had a self-contained narrow-gauge line, used to transport parts internally. The staff decided they wanted an engine with a cab, and chose as a prototype ALCo's #1173, which was specially built for a sugar plantation line in Cuba. Some artistic licence was taken, as the original #1173 is a standard gauge locomotive. Victor made multiple further appearances in the thirteenth series, and has appeared in every series and special since.