LRG

LRG may refer to:

Science and technology

  • Lateral rotator group, a collection of external hip rotators in the human body
  • Locus Reference Genomic, DNA sequence format
  • Luminous red galaxy, analysed by fractal cosmology

    • Organisations

  • Life Raft Group, an international gastrointestinal stromal tumor patient support organization and participant in The Redstone Acceleration & Innovation Network
  • Lifted Research Group, urban clothing line
  • LRG University of Applied Sciences, a Swiss private university with a famous hotel management program
  • Ludlow Research Group, an association of professional geologists

    • Other

  • Lairg railway station, Scotland, by National Rail code

    • See also

  • LIRG (disambiguation)
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    This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/LRG

    LRG1

    Leucine-rich alpha-2-glycoprotein 1 is a protein which in humans is encoded by the gene LRG1.

    Function

    The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation.

    LRG1 has been shown to be involved in promoting neovascularization (new blood vessel growth) through causing a switch in transforming growth factor beta (TGFbeta) signaling in endothelial cells. LRG1 binds to the accessory receptor endoglin and promotes signaling via the ALK1-Smad1/5/8 pathway.

    Application

    Levels of the LRG protein are markedly elevated in acute appendicitis and therefore could be used as a diagnostic aid.

    LRG1 may be a potential therapeutifc target for the treatment of diseases where there is aberrant neovascularization.

    References

    Further reading

    This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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    This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/LRG1

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