Ago

Ago or AGO may refer to:

People

Places

Other uses

Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Lonely

Lonely may refer to:

See also

Lonely (Tracy Lawrence song)

"Lonely" is a song written by Robin Lee Bruce and Roxie Dean, and recorded by American country music artist Tracy Lawrence. It was released in May 2000 as the second single from the album Lessons Learned. The song reached #18 on the Billboard Hot Country Singles & Tracks chart.

Chart performance

Year-end charts

References

External links

Lonely (2NE1 song)

"Lonely" is the second single by South Korean girl group 2NE1 from their 2011 extended play, 2NE1. Later that year, a Japanese version of the song was released and was included on their first Japanese EP Nolza. A short version of the music video was uploaded through 2NE1's official YouTube account.

Background

The song was written and produced by Teddy Park. According to the CEO of YG Entertainment, Yang Hyun Suk, "2NE1’s new song counter feeds the people with an analogue sound unlike the majority who used strong electronics and house music and maybe that is why Will I. Am have [sic] found it interesting". They also released teasers of "Lonely" starting with CL and Minzy on May 9, and Dara and Bom on May 10. The music video was released on May 11, 2011.

Chart performance

By the end of 2011, "Lonely" was downloaded 2,935,930 times, and reached the fourteenth position in the 2011 Gaon Year-End Chart, becoming the third-highest charting of 2NE1's 2011 singles.

Music video

The music video for "Lonely" was filmed April 27, 2011, directed by Han Samin, who directed the music video for Big Bang's fourth mini-special album's title song, "Love Song". The video was posted on their YouTube account on May 11, 2011.