PON
PON or Pon may refer to:
Business
Technology
Medicine/Chemistry
Religion
Fiction
Other
PON1
Serum paraoxonase/arylesterase 1 (PON1) also known as A esterase , homocysteine thiolactonase or serum aryldialkylphosphatase 1 is an enzyme that in humans is encoded by the PON1 gene. Paraoxonase 1 has esterase and more specifically paraoxonase activity. Serum PON1 is found in all mammalian species studied so far but is not present in the serum of birds, fish and reptiles or in insects. PON1 is the first discovered member of a multigene family also containing PON2 and PON3, the genes for which are located adjacent to each other on chromosome 7.
Structure
Human PON1 is a glycoprotein composed of 354 amino acids and has a molecular weight of 43000 Daltons which associates with high-density lipoprotein (HDL, "good cholesterol") in the circulation. Serum PON1 is secreted mainly by the liver although local synthesis occurs in several tissues and PON1 protein is found in almost all tissues. X-ray crystallography has revealed the structure of PON1 to be a 6 bladed propeller with a unique lid structure covering the active site passage and which allows association with HDL. The structure contains 2 calcium ions which are essential for catalytic activity and enzyme stability.
Loló
Lourenço Tomás Cuxixima, commonly known as Loló (born 3 December 1981) is an Angolan footballer who plays as a forward.
Loló appeared in one match for the Angola national team, in 2002.
National team statistics
References
External links
Lolá
Lolá is a corregimiento in Las Palmas District, Veraguas Province, Panama with a population of 946 as of 2010. Its population as of 1990 was 960; its population as of 2000 was 1,022.
References
Coordinates: 8°06′00″N 81°28′00″W / 8.1000°N 81.4667°W / 8.1000; -81.4667
Uniregistry
Uniregistry is a Cayman Islands-based domain name registry that administers the generic top-level domains .audio, .auto, .blackfriday, .car, .cars, .christmas, .click, .diet, .flowers, .game, .gift, .guitars, .help, .hiphop, .hiv, .hosting, .juegos, .link, .lol, .mom, .photo, .pics, .property, .sexy, and .tattoo. In February 2012, the related company Uniregistrar Corporation became an ICANN-accredited registrar and launched under the licensed Uniregistry brand name in 2014.
History
Uniregistry Corporation was officially founded in 2012 by Frank Schilling, one of the largest private domain name portfolio owners in the world, and registered in the Cayman Islands. However, the domain Uniregistry.com was registered six years earlier and the company filed an intent to use the name in the Cayman Islands in 2010. Trademark applications for the "Uniregistry" mark and its stylized "U" logo were filed in 2012. That year, Schilling invested $60 million and applied for 54 new top-level domains. Uniregistrar Corporation became an ICANN-accredited registrar in February 2013. In January 2014, Uniregistry Inc. became a subsidiary in Newport Beach, California to house a West Coast service and support team. The registrar began operating under the licensed Uniregistry brand name in 2014. Uniregistry's registry infrastructure was designed by Internet Systems Consortium (ISC) and Uniregistry subsequently purchased its infrastructure in 2013.
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