Lesparre-Médoc (Occitan: L'Esparra) is a commune in the Gironde department in Aquitaine in southwestern France. It is a sub-prefecture of the department.
Lesparre is on the Médoc peninsula about 80 km north of Bordeaux.
In the High Middle Ages it was the site of castle. The troubadour Aimeric de Belenoi was born here.
Lesparre is twinned with Drayton in the Vale of White Horse, Oxfordshire, England.