Leslie Charleson (born February 22, 1945) is an American actress, best known for her role as Monica Quartermaine in the ABC daytime soap opera, General Hospital.
Charleson was born in Kansas City, Missouri. Her sister is actress Kate Charleson, who died in 1996. Her career began on short-lived ABC daytime soap opera, A Flame in the Wind in 1964. In 1966 she joined the cast of As the World Turns for the one year. From 1967 to 1970 she starred on the CBS soap opera, Love Is a Many Splendored Thing. She played the role of Iris Donnelly Garrison. Her character was a part of a highly popular love triangle with David Birney and Donna Mills.
In 1970, Charleson leaving daytime television and began career on primetime. She guest starred on the many series from 1970 to 1977, including Emergency!, Ironside, Marcus Welby, M.D., Happy Days, Cannon, The Streets of San Francisco, and The Rockford Files. She had supporting role in the 1973 science-fiction film, The Day of the Dolphin, and co-starred opposite Shelley Winters in the made for television thriller Revenge (1971). Charleson also had the leading roles in a number of unsuccessful television pilots.