After lecturing at Makerere University, Kampala from 1971-3 and Sheffield City Polytechnic from 1973–80, he joined what is now the University of Plymouth in 1981 as a lecturer in Analytical Chemistry. In 1989 he was promoted to Head of Department of Environmental Sciences and eventually rose to Deputy Vice-Chancellor (Academic Development).
Ebdon's research interests are in environmental analytical chemistry and his various contributions to our understanding of the behaviour and importance of trace elements in the environment have led to over 250 publications and to several awards.