Lanosterol

Lanosterol is a tetracyclic triterpenoid and is the compound from which all animal and fungi steroids are derived. By contrast plant steroids are produced via cycloartenol.

Role in creation of steroids

Elaboration of lanosterol under enzyme catalysis leads to the core structure of steroids. 14-Demethylation of lanosterol by CYP51 eventually yields cholesterol.

Recent research suggests that lanosterol might be instrumental in prevention of formation of cataracts in mammals.

Biosynthesis

Clinical significance

Preliminary studies in dogs and rabbits have shown that lanosterol can prevent and even reverse cataract formation.

See also

  • Cycloartenol
  • CYP51
  • References

  • E. J. Corey, W. E. Russey, P. R. Ortiz de Montellano (1966). "2,3-Oxidosqualene, an Intermediate in the Biological Synthesis of Sterols from Squalene". Journal of the American Chemical Society 88 (20): 4750–4751. doi:10.1021/ja00972a056. PMID 5918046. 
  • I. Abe, M. Rohmer, G. D. Prestwich (1993). "Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes". Chemical Reviews 93 (6): 2189–2206. doi:10.1021/cr00022a009. 
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