LAG3

Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000, is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders. In soluble form it is also being developed as a cancer drug in its own right.

Gene

The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. The gene for LAG-3 lies adjacent to the gene for CD4 on human chromosome 12 (12p13) and is approximately 20% identical to the CD4 gene

Protein

The LAG3 protein, which belongs to immunoglobulin (Ig) superfamily, comprises a 503-amino acid type I transmembrane protein with four extracellular Ig-like domains, designated D1 to D4. When human LAG-3 was cloned in 1990 it was found to have approx. 70% homology with murine LAG3. The homology of pig LAG3 is 78%.

Lag

In online gaming, lag is a noticeable delay between the action of players and the reaction of the server in a video game. Although lag may be caused by high latency, it may also occur due to insufficient processing power in the client (screen-lag). Screen-Lag can also happen in single player games as well.

The tolerance for lag depends heavily on the type of game. For instance, a strategy game or a turn-based game with a low pace may have a high threshold or even be mostly unaffected by high delays, whereas a twitch gameplay game such as a first-person shooter with a considerably higher pace may require significantly lower delay to be able to provide satisfying gameplay. But, the specific characteristics of the game matter. For example, fast chess is a turn-based game that is fast action and may not tolerate high lag. And, some twitch games can be designed such that only events that don't impact the outcome of the game introduce lag, allowing for fast local response most of the time.

Causes

Mariano Lagasca

Mariano la Gasca y Segura (1776–1839) was a Spanish botanist, writer and doctor. He was the director of Royal Botanical Garden of Madrid.

Early life

Mariano la Gasca y Segura was born in Zaragoza, in Spain on October 4, 1776, to a wealthy Catholic family. He studied at the local elementary school and afterwards he continued his ecclesiastical studies in Tarragona. During his studies in Tarragona he developed an interest for medicine and botany. After finishing his studies in Tarragona, he started travelling until eventually studying medicine at first in Zaragoza, and later in Valencia and Madrid.

Career

In 1800 he moved to Madrid where he met Antonio José Cavanilles, a well-known botanist and doctor and became his disciple. In Madrid he cooperated in various fields José Demetrio Rodriguez, and co-published with him a botanical book titled Description of certain plants of the Royal Botanical Garden of Madrid (Spanish: 'Descripción de algunas plantas del Real Jardín Botánico de Madrid') in 1801.

Lag (disambiguation)

Lag refers to slower response time (or latency), and to delays experienced in computing, communications, and engineering. (see also Lag (online gaming)).

Lag may also refer to:

Lagging is mainly used in the following senses: