Diana, Princess of Wales

Diana, Princess of Wales (Diana Frances;née Spencer; 1 July 1961 – 31 August 1997), was the first wife of Charles, Prince of Wales, who is the eldest child and heir apparent of Queen Elizabeth II.

Diana was born into a family of British nobility with royal ancestry as The Honourable Diana Spencer. She was the fourth child and third daughter of John Spencer, 8th Earl Spencer and the Honourable Frances Shand Kydd. She grew up in Park House, situated on the Sandringham estate, and was educated in England and Switzerland. In 1975, after her father inherited the title of Earl Spencer, she became Lady Diana Spencer.

Her wedding to the Prince of Wales on 29 July 1981, held at St Paul's Cathedral, reached a global television audience of over 750 million people. While married, Diana bore the titles Princess of Wales, Duchess of Cornwall, Duchess of Rothesay, Countess of Chester, and Baroness of Renfrew. The marriage produced two sons, the princes William and Harry, who were then respectively second and third in the line of succession to the British throne. As Princess of Wales, Diana undertook royal duties on behalf of the Queen and represented her at functions overseas. She was celebrated for her charity work and for her support of the International Campaign to Ban Landmines. From 1989, she was the president of Great Ormond Street Hospital for children, in addition to dozens of other charities.

List of EastEnders characters (2013)

The following are characters who first appeared, or returned, in the BBC soap opera EastEnders during 2013 listed by order of first appearance . New characters were introduced by Lorraine Newman, executive producer until December 2013, when Dominic Treadwell-Collins took over.

The first character to be announced was Dexter Hartman, the teenage son of Ava Hartman. He was introduced in January. Steve Lowe, Bianca Butcher's probation officer and a love interest for Carol Jackson, arrived as a recurring character in February, and in March, Kane and his gang appeared for a storyline involving Liam Butcher. Dexter's father Sam James arrived in May. Kirsty Branning's ex-boyfriend Carl White joined the show in June. Two short-term characters, Betty Spragg, and Ollie Walters, arrived in July. Sadie Young arrived on the show in August, as the new owner of the beauty salon. Former Hollyoaks actor Jamie Lomas made his first appearance in August as well, playing Jake Stone. Upon the announcement that established character David Wicks was returning to the show, Lisa Maxwell was cast as his girlfriend, Naomi, who appeared in September for one episode. Terry Alderton, playing Terry Spraggan, made his debut in November, along with his children TJ and Rosie. Former Holby City actress Luisa Bradshaw-White was cast as Tina, who first appeared in November, followed in December by Mick Carter (Danny Dyer), Linda Carter (Kellie Bright), his partner, and their younger son, Johnny (Sam Strike).

C&A

C&A is an international Dutch chain of fashion retail clothing stores, with its European head offices in Vilvoorde, Belgium, and Düsseldorf, Germany. It has retail stores in many countries in Europe, Central America and South America. Its brands include Angelo Litrico, Canda, Clockhouse, Here+There, Palomino, Rodeo (ski and snowboard clothes), Westbury, Yessica, Yessica Pure, and Your Sixth Sense.

The company was founded by brothers Clemens and August Brenninkmeijer in 1841 as a Dutch textile company, taking its company name from their initials. In 1906 Clemen's son, Bernard Joseph, started discounting in Amsterdam (Rekenen in Centen, in plaats van Procenten) and by 1910 there were ten stores in the Netherlands. They were from the German Brenninkmeyer family which traded in linen and textiles since the 17th century from its hometown of Mettingen, Germany.

For many years, C&A retail clothing stores were a major presence on high streets throughout the United Kingdom. C&A also opened stores in a number of out-of-town locations, most notably its store at the Merry Hill Shopping Centre in the West Midlands, which opened in November 1989. The company's strategy of selling budget clothes from high-rent city-centre retail stores made it vulnerable to a new breed of competitors operating in cheaper, out-of-town locations, including Matalan and the rapidly expanding clothing operations of supermarket food chains such as Tesco and Asda, and to expanding high street names such as H&M, Zara, and Topshop.

Côa River

The Côa River is a tributary of the Douro River, in central and northeastern Portugal. It is one of the few Portuguese rivers that flows south to north. It flows through the municipalities of Sabugal Municipality, Almeida Municipality, Pinhel Municipality, Figueira de Castelo Rodrigo Municipality and Vila Nova de Foz Côa Municipality, all located in the Guarda District.

Thousands of ancient carvings in stone were discovered in the Côa Valley in the 1980s and 1990s. These are of particular interest due to the high concentration of Paleolithic art, and because these carvings are found outside of caves, on rocks in plain sight: Jean Clottes, a prominent French prehistorian, had confirmed that "is the biggest open air site of paleolithic art in Europe, if not in the world".

The drawings attracted worldwide attention when plans to build a hydroelectric dam across the Côa Valley threatened to submerge them. Although hydroelectric development was already well underway, outcry from locals, the scientific community and the media led to dam construction being halted in 1995 after a change in the national government following elections. A significant proportion of the drawings in the Canada do Inferno area were already underwater by that time. The Côa Valley Archaeological Park, opened in 1996 , was declared a protected UNESCO world heritage site in 1998.

Complement component 4

Complement component 4 is a protein involved in the complement system.

It is cleaved into proteins 4a and 4b; 4b can be further cleaved into 4c and 4d.

Clinical significance

It is responsible for the Chido Rodgers blood group system.

C4d has been identified as a biomarker for systemic lupus erythematosus.

The gene that codes for C4 is being investigated for the role it may play in schizophrenia risk and development.

References