LSM may refer to:
In molecular biology, LSm proteins are a family of RNA-binding proteins found in virtually every cellular organism. LSm is a contraction of 'like Sm', because the first identified members of the LSm protein family were the Sm proteins. LSm proteins are defined by a characteristic three-dimensional structure and their assembly into rings of six or seven individual LSm protein molecules, and play a large number of various roles in mRNA processing and regulation.
The Sm proteins were first discovered as antigens targeted by so-called Anti-Sm antibodies in a patient with a form of Systemic lupus erythematosus (SLE), a debilitating autoimmune disease. They were named Sm proteins in honor of Stephanie Smith, a patient who suffered from SLE. Other proteins with very similar structures were subsequently discovered and named LSm proteins. New members of the LSm protein family continue to be identified and reported.
Proteins with similar structures are grouped into a hierarchy of protein families, superfamilies, and folds. The LSm protein structure is an example of a small beta sheet folded into a short barrel. Individual LSm proteins assemble into a six or seven member doughnut ring (more properly termed a torus), which usually binds to a small RNA molecule to form a ribonucleoprotein complex. The LSm torus assists the RNA molecule to assume and maintain its proper three-dimensional structure. Depending on which LSm proteins and RNA molecule are involved, this ribonucleoprotein complex facilitates a wide variety of RNA processing including degradation, editing, splicing, and regulation.
Mexican Sign Language (“lengua de señas mexicana” or LSM, also known by several other names), is the language of the Deaf community in the urban regions of Mexico. It is the primary language of 87,000 to 100,000 people (1986 T. C. Smith-Stark).
Core signing populations are found in Mexico City, Guadalajara and Monterrey, with a number of smaller cities containing signing communities. Some regional variation is found (80%-90% lexical similarity across the country according to Faurot et al. 2001).
Variation is high between age group and people of completely different religious backgrounds.
LSM is quite distinct from Spanish, with completely different verb inflections, different discourse structure and preferences for word order, and little use of the verb to be. However, there is extensive use of initialised signs with one study finding 37% of a 100-word list are initialised, compared to 14% for American Sign Language (Faurot et al. 2001). The same authors suggest that the Deaf community's comprehension of the Spanish language is very low.
I wanna lose my way
And my sense of direction
Wanna lose my bearings
And my point of reference
Wanna go where everything
Don't remind me of our happiness
That we sacrificed for some unknown bliss
I wanna lose my place
In this world I've created
To know who I am
It's so overrated
Wanna break away until my longing has fated
Wanna change my fate
Wanna dream again
Go out dancing
I wanna laugh again
Till I lose my mind
Heavy heart when will you fall?
Again from the weight of this longing?
Inside of me I believe
I thought I found, found me a home
But all I want is to run away
Run from my life tonight
I wanna lose my way
And my sense of direction
Wanna lose my bearings