LRP6
Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.
Structure
LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. In each protein, about 85% of its 1600-amino-acid length is extracellular. Each has four β-propeller motifs at the amino terminal end that alternate with four epidermal growth factor (EGF)-like repeats. Most extracellular ligands bind to LRP5 and LRP6 at the β-propellers. Each protein has a single-pass, 22-amino-acid segment that crosses the cell membrane and a 207-amino-acid segment that is internal to the cell.
Function
LRP6 acts as a co-receptor with LRP5 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway.
Interactions
Canonical WNT signals are transduced through Frizzled receptor and LRP5/LRP6 coreceptor to downregulate GSK3beta (GSK3B) activity not depending on Ser-9 phosphorylation. Reduction of canonical Wnt signals upon depletion of LRP5 and LRP6 results in p120-catenin degradation.
LRP1
Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the LRP1 protein is encoded by the LRP1 gene. LRP1 is also a key signalling protein and, thus, involved in various biological processes, such as lipoprotein metabolism and cell motility, and diseases, such as neurodegenerative diseases, atherosclerosis, and cancer.
Structure
The LRP1 gene encodes a 600 kDa precursor protein that is processed by furin in the trans-Golgi complex, resulting in a 515 kDa alpha-chain and an 85 kDa beta-chain associated noncovalently. As a member of the LDLR family, LRP1 contains cysteine-rich complement-type repeats, EGF (gene) repeats, β-propeller domains, a transmembrane domain, and a cytoplasmic domain. The cytoplasmic domain of LRP1 is the alpha-chain, which comprises four ligand-binding domains (numbered I-IV) containing two, eight, ten, and eleven cysteine-rich complement-type repeats, respectively. These repeats bind extracellular matrix proteins, growth factors, proteases, protease inhibitor complexes, and other proteins involved in lipoprotein metabolism. Of the four domains, II and IV bind the majority of the protein’s ligands. The EGF repeats and β-propeller domains serve to release ligands in low pH conditions, such as inside endosomes, with the β-propeller postulated to displace the ligand at the ligand binding repeats. The transmembrane domain is the β-chain, which contains a 100-residue cytoplasmic tail. This tail contains two NPxY motifs that are responsible for the protein’s function in endocytosis and signal transduction.
LRP5
Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.
Structure
LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. In each protein, about 85% of its 1600-amino-acid length is extracellular. Each has four β-propeller motifs at the amino terminal end that alternate with four epidermal growth factor (EGF)-like repeats. Most extracellular ligands bind to LRP5 and LRP6 at the β-propellers. Each protein has a single-pass, 22-amino-acid segment that crosses the cell membrane and a 207-amino-acid segment that is internal to the cell.
Function
LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis.
Podcasts:
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by Cross Movement
Llrp
by: Cross Movement[Chorus]
Life, Liberty, Righteousness, and the puruist thereof
It's tight, might just get, too rough to travel this road
But it's good to know, that for my soul, Christ is in control
Life, Liberty, Righteousness, and the puruist thereof
It's tight, might just get, too tough to travel this road
But it's good to know, that for my soul, Christ is in control
[T.R.U-L.I.F.E.]
Since the beginning of my life wit Christ its been shady
Im not crazy, my light hasn't been bright but hazy
Dimmed my desires within and fulfilment of my flesh
And best, let's just call it sin
It is what it is, so Ima deal wit this thing
Put my biz in the street but be real for the king
Even if it kills me, cause I've got a strange feelin
Some will draw close, and others wont cause quite revealin
Dont worry Im not mentionin names or situations
Just makin in plain wit some internal observations
Keepin it straight wit all the points that Im statin
So you dont get tossed, fooled or twisted by Satan
Now take it
[Chorus]
[2x]
[T.R.U-L.I.F.E.]
The wild things is, Ive been actin my childish
But Im a king's kid, so there's no hints of foulness
But such a loudness, that its clearly unmistakable
My Lord and Savior subjected Himself to a breakable
Shell that would be impaled, nailed but would rip the vale
And provide a detour for those on their way to hell
Not to tell, well that would not do Him any justice
Like me for eternity, many have entrusted
Themselves to His plan, His hand is fool proof
All God and all man, stands together as pure truth
I fall face in hand, His cures from the root
Cleans from the heart, makes a man new
I've seen what He can do
[Chorus]
[2x]
[T.R.U-L.I.F.E.]
I've had a sob story for a long time
But this aint bout a kid, who trippedup, fell down or lagged behind
But a story of one whose overcome, wit and by the Son
Spit fire wit the tongue, lift Messiah til Im done
The war's be done, but the battle jus begun
Victory has I run persevere' cause Christ hung
Breath left His lung, death poked fun
And the King ressurected and guess what?
Death got thumped! No longer wit the power to slump
A man if he believes, he cant be plucked
From the hand of the son
Who to trust, and why do you trust this One?
And when your physicals don? Have they told you what comes?
Life is more then just money, sex, drugs and guns
I know it dont sound fun but Ive got the right One
And when I do die, my life has just begun
How could I ever forget the dust is where Im from?
To the face of opposition I laught It's been engrafted
My righteousness is part of this total package
And so is my eternal secruity
That's why in all things I do now you can see me chasin purity
Goodness, gratefulness, lovein-kindness
To live a live of liberty and righteousness for his Highness
I see Lord, thanks for removin all the blindness
And pressin this coal into an H-Class diamond
[Chorus]