LPHN3

Latrophilin-3 is a protein that in humans is encoded by the ADGRL3 gene.

Function

This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.

Clinical significance

A version of this gene has been linked to Attention Deficit/Hyperactivity Disorder (ADHD).

See also

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.